Oxacillin Sodium Monohydrate, identified by CAS number 7240-38-2, stands as a crucial pharmaceutical compound within the antibiotic landscape. As a semisynthetic penicillinase-resistant β-lactam antibiotic, it is highly valued for its efficacy, particularly against challenging Gram-positive bacterial infections. This compound has carved out a significant role in clinical microbiology and therapeutic applications, offering a reliable solution where older antibiotics might fall short due to bacterial resistance mechanisms.

Chemically, Oxacillin Sodium Monohydrate presents as a white powder, with a molecular formula of C19H20N3NaO6S and a molecular weight of 441.43. Its high purity, typically exceeding 99%, ensures its reliability for pharmaceutical use. For optimal stability and shelf life of approximately 24 months, it should be stored in a cool, dry place. Compliance with stringent quality certifications such as GMP, HSE, ISO 9001, USP, and BP underscores its suitability for a wide range of applications, ensuring both safety and effectiveness.

The mechanism of action of Oxacillin is rooted in its ability to disrupt bacterial cell wall synthesis. Like other β-lactam antibiotics, it interferes with the activity of Penicillin-Binding Proteins (PBPs), which are critical enzymes involved in the final stages of peptidoglycan synthesis. This interference prevents the proper formation of crosslinks in the bacterial cell wall, leading to compromised cell wall integrity, osmotic instability, and ultimately, bacterial cell lysis and death. A key distinguishing feature of Oxacillin is its resistance to penicillinase enzymes, which are commonly produced by bacteria to inactivate many penicillin-based antibiotics. This inherent resistance makes it particularly effective against strains that have developed this common form of drug resistance.

Oxacillin exhibits a narrow spectrum of activity, primarily targeting Gram-positive organisms. It is notably effective against resistant Staphylococcus species, including certain strains of Staphylococcus aureus and Staphylococcus epidermidis. Historically, Oxacillin has largely replaced methicillin in clinical practice for treating penicillin-resistant Staphylococcus aureus infections. Its utility extends beyond direct treatment; in microbiology laboratories, Oxacillin Sodium is indispensable for in vitro antimicrobial susceptibility testing (AST). It is commonly incorporated into panels, discs, and MIC strips to determine the minimum inhibitory concentrations (MIC) against microbial isolates, guiding medical microbiologists in recommending appropriate antibiotic treatment options. Furthermore, it can serve as a selective agent in various isolation media, such as ORSAB Selective Supplement.

However, the widespread use of antibiotics, including Oxacillin, has unfortunately led to the emergence of highly resistant strains. Oxacillin-resistant Staphylococcus aureus, widely known as MRSA (Methicillin-Resistant Staphylococcus aureus) or ORSA, represents a significant public health challenge globally. While Oxacillin is effective against penicillinase-producing strains, MRSA/ORSA exhibits a different resistance mechanism, rendering Oxacillin ineffective. Such highly resistant infections typically require treatment with alternative antibiotics, like vancomycin.

For those looking to procure high-quality Oxacillin Sodium Monohydrate, it is essential to connect with a reputable manufacturer and supplier. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing pharmaceutical raw materials that meet stringent industry standards. When you are ready to buy Oxacillin Sodium Monohydrate or explore its current price, seeking direct engagement with a professional supplier can streamline your purchase process and ensure product integrity. Our commitment to quality and service makes us a trusted partner for your pharmaceutical ingredient needs.