Hypromellose, also known as Hydroxypropyl Methylcellulose (HPMC), is a widely recognized and indispensable excipient in the pharmaceutical industry. Among its various grades, HPMC E5 stands out due to its specific viscosity and substitution pattern, making it particularly suited for numerous critical applications, especially in the formulation of oral solid dosage forms. NINGBO INNO PHARMCHEM CO.,LTD. focuses on providing high-quality pharmaceutical grade HPMC E5 powder, adhering to stringent international pharmacopoeial standards such as USP, BP, EP, and CP.

HPMC E5 is chemically defined as 2-hydroxypropyl methylcellulose, derived from cellulose. It typically presents as a white or off-white fibrous or granular powder. It is odourless and tasteless, characteristics vital for its use in pharmaceutical and food applications. While it is practically insoluble in anhydrous ethanol, ether, or acetone, it exhibits excellent solubility in cold water, forming a clear to slightly turbid colloidal solution upon hydration. This unique solubility profile is key to its functionality, allowing for easy preparation of solutions for film coating or granulation processes.

The 'E' series of HPMC is characterized by a higher degree of methoxy substitution and a lower degree of hydroxypropoxy substitution compared to other grades like the 'K' series. The 'E5' designation commonly refers to a specific viscosity range, typically around 3-6 mPa.s for a 2% aqueous solution at 20°C, corresponding to USP Type 2910. This controlled viscosity is crucial for achieving desired performance in various applications, particularly in film coating where precise solution properties are needed for uniform and defect-free layers.

One of the primary applications of Pharmaceutical Grade HPMC E5 is as a material for capsule shells, especially in the production of vegetarian or plant-based capsules. As a safe and inert polymer, it serves as an excellent alternative to gelatin, catering to dietary and cultural requirements. HPMC capsules offer advantages such as low moisture content, stability across a wide range of temperatures and humidities, and suitability for moisture-sensitive active pharmaceutical ingredients (APIs). The film-forming capability of HPMC E5 ensures robust yet easily digestible capsule shells.

Another significant application is its use in tablet film coating. HPMC E5 solutions can be applied to tablet cores to form a thin, smooth, and durable coating. This coating serves multiple purposes: it protects the API from moisture, light, and oxygen; masks unpleasant tastes or odors; facilitates swallowing; improves aesthetic appearance; and can influence drug release profiles (though other HPMC grades might be more common for controlled release matrices, E5 is excellent for immediate release or protective coatings). The low viscosity of E5 is advantageous for preparing coating solutions with high solid content, allowing for faster coating processes while maintaining good sprayability and film properties such as adhesion, strength, and elasticity.

Beyond capsule shells and film coatings, HPMC E5 also functions effectively as a binder in tablet granulation. Its binding properties help to hold powders together, forming granules with improved flow characteristics and compressibility, leading to stronger tablets with reduced friability. It can be used in both wet and dry granulation processes. Furthermore, its ability to swell in water makes it useful as a suspending agent or thickening agent in liquid pharmaceutical formulations, helping to maintain uniformity and stability of suspensions.

The pharmaceutical industry demands excipients of the highest purity and consistency. Pharmaceutical Grade HPMC E5 meets these rigorous requirements. Its inert, non-ionic nature means it generally does not interact with APIs, ensuring drug stability and bioavailability. It is metabolically inert and non-toxic, making it safe for ingestion. These properties, combined with its reliable performance as a film former, binder, and suspending agent, solidify its position as a cornerstone excipient.

Ensuring a reliable supply chain for High Quality Pharmaceutical Grade HPMC E5 Powder is paramount for pharmaceutical manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. understands the critical need for consistent quality and availability. For pharmaceutical companies seeking a trusted manufacturer and supplier of HPMC E5, accessing detailed product specifications and quality documentation is essential. We provide comprehensive information on our HPMC E5 to meet the strict validation requirements of the pharmaceutical sector.

Understanding the price structure and minimum order quantities is crucial for procurement planning. Information on the competitive price for pharmaceutical grade HPMC E5 is available, reflecting the balance between quality, compliance, and cost-effectiveness. Potential buyers interested in the price or looking to buy this essential excipient can easily obtain the necessary details for procurement.

Procuring HPMC E5 requires confidence in the source. NINGBO INNO PHARMCHEM CO.,LTD. facilitates the process for companies looking to purchase reliable HPMC E5. Details regarding packaging, such as the standard 25kg fiber drums, storage conditions (cool, dry place below 30°C, protected from humidity and pressing), and validity period (typically 2 years), are readily provided to ensure proper handling and storage upon receipt. Partnering with a reputable manufacturer ensures not only product quality but also consistency batch after batch, which is vital for maintaining the integrity and efficacy of the final drug product.

In conclusion, Pharmaceutical Grade HPMC E5 Hypromellose Powder is a highly versatile and essential excipient for the pharmaceutical industry, critical for modern capsule shells and film coating technologies, as well as serving effectively as a binder. Its advantageous properties, coupled with adherence to global pharmacopoeial standards, make it a preferred choice for formulators. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being a trusted supplier, offering high-quality HPMC E5 and comprehensive support to facilitate informed decisions for those looking to buy or purchase this key raw material at a competitive price.