Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Trazodone HCl, a significant compound in the pharmaceutical landscape, is recognized for its multifaceted pharmacological profile. As a serotonin antagonist and reuptake inhibitor (SARI), its primary action involves modulating neurotransmitter levels in the brain, particularly serotonin. This mechanism is key to its effectiveness in treating conditions such as major depressive disorder, anxiety disorders, and insomnia. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality Trazodone HCl that meets stringent pharmaceutical standards, ensuring efficacy and reliability in its applications.
The binding profile of Trazodone HCl reveals its affinity for various serotonin receptors, including antagonist activity at 5-HT2A and 5-HT2B receptors, and partial agonism at the 5-HT1A receptor. Furthermore, it exhibits antagonism at α1-adrenergic receptors. Understanding these interactions is crucial for appreciating its therapeutic benefits and potential side effects. The active metabolite, m-chlorophenylpiperazine (mCPP), also contributes to its overall pharmacological action, though its specific role and impact are subjects of ongoing research.
The metabolism of Trazodone HCl primarily occurs in the liver, involving cytochrome P450 enzymes like CYP3A4, CYP2D6, and CYP1A2. This metabolic pathway is important for patients to consider, especially when taking other medications that might affect these enzymes, as this could alter drug concentrations and efficacy. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its Trazodone HCl is produced with consistent quality, supporting the reliable pharmaceutical applications of Trazodone HCl in treatment regimens.
The efficacy of Trazodone HCl in treating depression is well-documented, offering a viable option for patients who may not respond to other antidepressants. Its sedative properties also make it a valuable tool for managing insomnia, a common comorbidity with mental health disorders. The research into the treatment of depression and insomnia continues to highlight the importance of compounds like Trazodone HCl. For those seeking reliable sourcing for pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. offers Trazodone HCl, facilitating advancements in mental health care.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
