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The field of peptide therapeutics is rapidly advancing, offering innovative solutions for challenging diseases. Among these advancements, synthetic peptides designed for targeted cancer therapy are showing immense promise. PNC-27, a synthetic anti-cancer peptide, represents a new generation of these therapeutics, offering a sophisticated approach to combating malignant cells.
At its core, PNC-27 is a membrane-active peptide. This designation signifies its ability to directly interact with and disrupt the cellular membrane. The specific target for PNC-27 is the HDM-2 protein, which is characteristically found on the surface of many cancer cells. By binding to HDM-2, PNC-27 initiates a mechanism that leads to the formation of pores within the cancer cell membrane. This process causes membranolysis, resulting in the targeted death of tumor cells through necrosis.
This mode of action is particularly noteworthy because it is highly selective. The differential expression of HDM-2 on cancer cells versus normal cells allows PNC-27 to exert its cytotoxic effects primarily on the intended targets. This selectivity is a significant advantage in minimizing off-target effects and improving the overall safety profile of potential cancer treatments. The precise PNC-27 cancer cell death mechanism is a subject of ongoing research and development.
Furthermore, PNC-27's therapeutic profile includes the crucial ability to induce tumor cell necrosis independently of the p53 pathway. The p53 tumor suppressor protein plays a vital role in cellular regulation, but its functionality can be compromised in many cancers. PNC-27's p53-independent action ensures its potential efficacy across a broader spectrum of cancers, including those with existing p53 mutations or inactivation. This makes the PNC-27 selective cancer therapy approach particularly promising.
As a leading manufacturer and supplier of high-quality peptides, NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of developing and providing compounds like PNC-27. We are dedicated to supporting the scientific community by offering reliable access to this innovative peptide for research purposes. If you are seeking to buy PNC-27 for your oncology studies, consider us your trusted partner. Our expertise in peptide synthesis ensures the quality and purity necessary for impactful research into new cancer treatments.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
