For pharmaceutical researchers and procurement specialists, understanding the pricing and availability of critical intermediates like Tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate (CAS: 571188-82-4) is essential for project planning and budget allocation. This compound, a key intermediate in the synthesis of Palbociclib, is a complex molecule, and its price and availability are influenced by several interconnected factors. If you are looking to buy this intermediate, especially from China, a strategic approach will ensure you secure a reliable supply at a competitive price.

Factors Influencing Price:

• Complexity of Synthesis: The multi-step synthesis required to produce Tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate involves specialized reagents, catalysts, and stringent reaction conditions. The inherent complexity of its organic synthesis directly contributes to its manufacturing cost.
• Purity Standards: Pharmaceutical intermediates demand high levels of purity (often ≥98.0%) to meet regulatory requirements and ensure the quality of the final API. Achieving and verifying this purity through rigorous analytical testing adds to the overall price.
• Raw Material Costs: The cost of precursor chemicals and specialized reagents used in the synthesis can fluctuate, impacting the final price of the intermediate.
• Production Volume: Generally, larger production volumes lead to economies of scale, potentially reducing the per-unit price. Buyers looking to purchase in bulk may negotiate better terms with manufacturers.
• Supplier and Manufacturer Location: The geographical location of the manufacturer can influence price due to differences in labor costs, environmental regulations, and raw material accessibility. Many suppliers in China offer competitive pricing due to their established chemical manufacturing infrastructure.
• Market Demand: As Palbociclib continues to be a significant therapeutic agent, the demand for its intermediates remains strong, influencing market pricing.

Ensuring Availability:

Securing a consistent supply is as important as price. When looking to buy Tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, consider:

• Reliable Suppliers and Manufacturers: Partnering with established chemical manufacturers, especially those with a strong reputation in China, is key. Look for suppliers that can provide Certificates of Analysis (CoA) and offer technical support.
• Lead Times and Production Capacity: Inquire about production lead times and the manufacturer's capacity to meet your required volume. Advance planning is crucial, especially for large-scale projects.
• Sample Availability: Before committing to a large purchase, request a sample to verify quality and suitability for your intended application.

For procurement professionals seeking to inquire about the price and availability of CAS 571188-82-4, contacting reputable chemical suppliers and manufacturers, particularly those based in China, is recommended. They can provide accurate quotes and discuss supply chain solutions tailored to your project needs. Securing a stable source of high-quality intermediates is fundamental to the successful development and manufacturing of life-saving pharmaceuticals.