Promethazine Hydrochloride (CAS 58-33-3) is a critical chemical intermediate extensively utilized in the pharmaceutical industry. Its unique chemical structure and properties make it an indispensable component in the synthesis of various medicinal compounds. For R&D scientists and formulators, understanding its nature and securing a reliable supply is paramount.

Chemical Profile and Properties

Promethazine Hydrochloride is a phenothiazine derivative with the molecular formula C17H20N2S·HCl and a molecular weight of approximately 320.88 g/mol. It typically presents as a white to off-white crystalline powder. Its solubility in water facilitates its incorporation into various dosage forms. The melting point is in the range of 230-232°C, indicating a stable crystalline structure suitable for handling and formulation.

As a pharmaceutical intermediate, its primary function is to serve as a building block or key ingredient in the manufacturing of finished pharmaceutical products. Its well-defined chemical synthesis pathways and consistent quality are essential for downstream drug production.

Therapeutic Role and Applications

The therapeutic applications of Promethazine Hydrochloride are diverse:

• Antihistaminic: It blocks histamine H1 receptors, relieving symptoms of allergies such as itching, sneezing, and runny nose.
• Antiemetic: It is effective in preventing and treating nausea and vomiting, particularly post-operative nausea and motion sickness.
• Sedative: It possesses central nervous system depressant effects, contributing to its use in inducing sleep or sedation before medical procedures.

When sourcing this compound, searching for 'Promethazine Hydrochloride supplier' or 'pharmaceutical intermediate CAS 58-33-3' will lead to dedicated chemical manufacturers. Prioritizing a supplier that guarantees high purity (e.g., 99%) and offers competitive 'Promethazine Hydrochloride price' is vital for cost-effective drug development.

Sourcing Considerations for Pharmaceutical Intermediates

For pharmaceutical companies, the sourcing of intermediates like Promethazine Hydrochloride involves rigorous vetting of suppliers. Key factors to consider include:

• Purity and Quality Assurance: Ensuring the intermediate meets specific pharmacopeial or internal quality standards is critical. Manufacturers in China are often primary sources for these high-quality chemicals.
• Supply Chain Reliability: A stable supply chain with consistent production capacity is necessary to avoid disruptions in drug manufacturing.
• Regulatory Compliance: The manufacturing process and product documentation must align with pharmaceutical industry regulations.
• Technical Support: Suppliers who offer technical data, samples, and responsive support are invaluable partners.

By partnering with reputable manufacturers of Promethazine Hydrochloride, pharmaceutical companies can ensure the quality and integrity of their final products, reinforcing their commitment to patient safety and therapeutic efficacy.