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For any chemist or procurement specialist, a thorough understanding of a chemical intermediate's properties is fundamental to its effective application and safe handling. 1-Bromo-2,3,4-trifluorobenzene (CAS 176317-02-5) is a compound of significant interest in the pharmaceutical and agrochemical industries, primarily due to its unique combination of a bromine atom and three fluorine atoms on a benzene ring.
The physical characteristics of 1-Bromo-2,3,4-trifluorobenzene are important for its integration into various processes. It is typically described as a clear liquid. Key physical properties often provided by manufacturers include its density, which is approximately 1.777 g/cm³, and its refractive index, usually around 1.4870. These parameters are critical for quality control and ensuring the material meets stringent specifications. The flash point, an indicator of flammability, is also an important safety consideration for handling and storage, reported around 62°C. Achieving a purity of 99% is a standard expectation for this compound when used in high-stakes applications.
Chemically, 1-Bromo-2,3,4-trifluorobenzene is highly valuable as a building block. The electron-withdrawing nature of the fluorine atoms activates the aromatic ring for certain reactions while also influencing the reactivity of the bromine atom. This makes it an excellent substrate for palladium-catalyzed cross-coupling reactions, which are widely used in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials. It can also readily form Grignard reagents, expanding its utility in carbon-carbon bond formation.
When sourcing 1-Bromo-2,3,4-trifluorobenzene, buyers should confirm that the supplier can provide detailed technical data sheets and Certificates of Analysis (CofA) that confirm these properties and the specified purity. For those looking to buy this intermediate from a reliable manufacturer in China, understanding these specifications ensures that the product will perform optimally in synthesis, whether for drug discovery, agrochemical development, or other fine chemical applications.
By familiarizing yourself with the precise properties of 1-Bromo-2,3,4-trifluorobenzene, you can make more informed purchasing decisions and effectively plan your chemical synthesis projects. Engaging with manufacturers who clearly communicate these details is key to a successful procurement process.
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