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For chemists and procurement specialists in the fine chemical industry, a deep understanding of the properties and applications of key intermediates is essential for efficient procurement and successful research. 2-Bromo-4-fluoro-1-nitrobenzene, identified by CAS number 700-36-7, is a halogenated aromatic nitro compound that offers a unique combination of functional groups, making it a versatile building block in organic synthesis.
Physically, 2-bromo-4-fluoro-1-nitrobenzene is typically described as a pale yellow to green solid. Its melting point is around 44°C, and it has a boiling point of approximately 224°C at atmospheric pressure. The density is reported as 1.808 g/cm³, and its refractive index is 1.579. These properties are crucial for handling, storage, and reaction planning. It is often stored in a dry, cool environment, sealed to prevent exposure to air, as recommended by many chemical suppliers.
Chemically, the presence of bromine, fluorine, and a nitro group on the benzene ring imparts specific reactivity. The bromine atom can participate in various coupling reactions (e.g., Suzuki, Sonogashira), while the nitro group can be reduced to an amine, opening pathways to a wide array of derivatives. The fluorine atom also influences the electronic properties of the ring and can be a point of substitution under certain conditions. This trifunctional nature makes 2-bromo-4-fluoro-1-nitrobenzene a highly sought-after intermediate for complex organic synthesis.
The primary applications of 2-bromo-4-fluoro-1-nitrobenzene lie in its role as a precursor. It is extensively used in the synthesis of pharmaceuticals, where it can form part of the core structure of active pharmaceutical ingredients (APIs). In the agrochemical industry, it serves as a building block for developing new pesticides and herbicides. Furthermore, its unique electronic characteristics make it a candidate for research in materials science, including the development of functional polymers and electronic materials.
When sourcing this compound, it is important to buy from reputable manufacturers who can guarantee purity and provide detailed specifications. For example, NINGBO INNO PHARMCHEM CO.,LTD. offers 2-bromo-4-fluoro-1-nitrobenzene with high purity, ensuring its suitability for demanding applications. Understanding these properties and applications empowers chemists and procurement managers to make informed decisions when purchasing this vital chemical intermediate.
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