In the realm of fine chemicals, understanding the detailed properties and potential applications of each compound is crucial for professionals in various industries, especially pharmaceuticals. This article provides a comprehensive overview of 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol (CAS 21928-50-7), a compound widely utilized as a pharmaceutical intermediate.

Chemical Identity and Physical Characteristics

4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is a chemical compound with the molecular formula C12H13ClF3NO and a molecular weight of 279.69. It is typically described as a beige fine crystalline powder. Key physical properties include:

• Melting Point: 138-141°C (Literature value)
• Density: Approximately 1.2685 (Estimated)
• Solubility: Soluble in methanol, indicating its utility in various solvent-based reactions.
• Appearance: Beige fine crystalline powder.

These characteristics are vital for proper handling, storage, and application in synthesis processes. The crystalline form and color are often initial indicators of purity and consistency.

Primary Applications in Pharmaceutical Synthesis

The most significant application of 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is its role as a key intermediate in the synthesis of pharmaceutical compounds. Its structure is particularly valuable for:

• Synthesis of Piperidinols: It serves as a direct precursor for various piperidinol derivatives, which are common structural motifs in many pharmaceutical drugs.
• Production of Penfluridol: It is a critical intermediate in the manufacturing of penfluridol, a long-acting antipsychotic medication. This application underscores its importance in the development of treatments for central nervous system disorders.

The compound's chemical reactivity allows it to participate in a range of organic synthesis reactions, making it a versatile component in the drug development pipeline. For companies looking to manufacture or research drugs that incorporate these structural elements, securing a reliable supply of this intermediate is essential.

Safety, Handling, and Storage Recommendations

As a chemical intermediate, 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is classified with certain hazards. It is typically indicated as causing skin irritation, serious eye irritation, and may cause respiratory irritation. Therefore, appropriate safety precautions must be observed:

• Personal Protective Equipment (PPE): Always wear suitable protective gloves, eye protection (goggles or face shield), and protective clothing when handling the compound.
• Handling: Ensure adequate ventilation. Avoid breathing dust or vapors. Wash hands thoroughly after handling.
• Storage: Store in a cool, dry place in a tightly closed container. It is recommended to protect it from light and store away from incompatible materials, such as strong oxidizing agents.

Adhering to these guidelines ensures the safety of personnel and maintains the integrity of the compound.

Choosing a Reliable Supplier

For consistent quality and reliable supply of 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol, partnering with experienced manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is recommended. We offer competitive pricing and ensure that our products meet the stringent quality standards required by the pharmaceutical industry. If you are looking to buy this intermediate or require further technical information, our team is ready to assist.