In the vast realm of chemical compounds, certain molecules stand out due to their versatility and critical role in industrial processes. 5-Chloro-2-thiophenecarboxylic acid, identified by its CAS number 24065-33-6, is one such compound. Possessing a unique chemical structure and a range of valuable properties, it has become a cornerstone intermediate, particularly within the pharmaceutical sector, but also in broader chemical applications.

Chemical Identity and Key Properties

5-Chloro-2-thiophenecarboxylic acid is an organic compound characterized by a thiophene ring. Attached to this ring are a chlorine atom at the 5-position and a carboxylic acid group at the 2-position. This arrangement results in a compound that typically appears as a cream-yellow powder. Its melting point is generally reported between 154-158°C, a key indicator of its purity. The molecule has a molecular weight of 162.59 g/mol and the molecular formula C5H3ClO2S.

The solubility of 5-Chloro-2-thiophenecarboxylic acid is noteworthy. While it exhibits low solubility in water, it is soluble in certain organic solvents like DMSO and methanol. This characteristic is vital for its processing in various chemical reactions and purification steps. The compound’s pKa is approximately 3.32, indicating its acidic nature due to the carboxylic acid group.

Applications Driving Demand

The primary driver for the production and use of 5-Chloro-2-thiophenecarboxylic acid is its indispensable role as an intermediate in the synthesis of Rivaroxaban. Rivaroxaban is a crucial anticoagulant medication used to prevent and treat serious blood clotting conditions. The reliable supply of high-purity 5-Chloro-2-thiophenecarboxylic acid is essential for the efficient manufacturing of this life-saving drug.

Beyond pharmaceuticals, this compound also serves as a valuable building block in organic synthesis. Its reactive functional groups allow chemists to introduce specific molecular modifications, leading to the creation of new chemicals with diverse properties. It is also explored for its potential in materials science and as a ligand in coordination chemistry, further broadening its utility.

Market Considerations for Chemical Buyers

For businesses seeking to acquire 5-Chloro-2-thiophenecarboxylic acid, understanding the market is crucial. Key considerations include the purity of the product, the reliability of the supplier, and the overall cost-effectiveness. Many chemical manufacturers, particularly in China, such as NINGBO INNO PHARMCHEM CO.,LTD., are major suppliers. When evaluating options, it is beneficial to research terms like '5-Chloro-2-thiophenecarboxylic acid manufacturers China' to identify trusted sources. The price can vary based on quantity, purity, and market demand, so obtaining quotes from multiple suppliers is advisable.

In summary, 5-Chloro-2-thiophenecarboxylic acid is a chemical compound of significant industrial importance. Its established role in pharmaceutical manufacturing, coupled with its potential in broader chemical applications, ensures its continued relevance and demand in the global market.