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For scientists and chemists involved in advanced organic synthesis, understanding the detailed properties and manufacturing processes of key intermediates is crucial. 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine (CAS 76041-71-9) is a compound that exemplifies the sophisticated nature of modern chemical building blocks, offering a unique combination of functional groups for diverse applications.
From a chemical perspective, this molecule possesses a pyridine core, which is a fundamental heterocyclic aromatic compound. The presence of a chlorine atom provides a site for nucleophilic substitution reactions, a common strategy in organic synthesis. The hydroxyl group offers another point for derivatization, such as esterification or etherification. Most notably, the trifluoromethyl (CF3) group significantly influences the molecule's electronic properties and lipophilicity. The strong electron-withdrawing nature of the CF3 group affects the reactivity of the pyridine ring, while its lipophilic character is highly beneficial in pharmaceutical and agrochemical applications, often enhancing membrane permeability and metabolic stability.
Physically, 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine is typically presented as a white to off-white solid, with a melting point in the range of 159-161 °C. This solid form simplifies handling and storage compared to liquids. Its molecular formula is C6H3ClF3NO, and it has a molecular weight of 197.54. These specifications are vital for accurate stoichiometric calculations and reaction planning.
The synthesis of this compound often involves selective chlorination of a precursor like 2-hydroxy-5-(trifluoromethyl)pyridine using agents such as N-chlorosuccinimide. As a leading manufacturer of this intermediate, our production processes are optimized for high yield and exceptional purity, typically exceeding 99%. We understand that for downstream applications, particularly in pharmaceutical development, the purity and consistency of intermediates are paramount. Therefore, when you buy this product from us, you are assured of its quality.
For procurement managers and R&D scientists seeking a reliable supplier of 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine, partnering with an experienced manufacturer in China like ourselves offers numerous advantages. We combine technical expertise with efficient production to deliver a superior product at competitive pricing. If your work requires this sophisticated building block, we encourage you to reach out for detailed technical information and quotation.
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