Quinine, identified by its Chemical Abstracts Service (CAS) number 130-95-0, stands as a historically and medically significant compound. This white crystalline powder, with the molecular formula C20H24N2O2 and a molecular weight of 324.417, is primarily known for its pivotal role in combating malaria, particularly strains caused by Plasmodium falciparum. Its journey from the bark of the South American cinchona tree to a global pharmaceutical staple highlights centuries of therapeutic use and scientific development.

Historically, indigenous communities in South America utilized cinchona bark as a potent fever reducer long before its introduction to the Western world. Quinine was the active ingredient responsible for these remarkable properties. Beyond its renowned antimalarial efficacy, it has also served as a mild antipyretic and analgesic, often found in common cold preparations. Furthermore, it has been successfully employed in the treatment of babesiosis and has shown promise in addressing certain muscular disorders, such as nocturnal leg cramps and myotonia congenita, due to its direct effects on muscle membranes and sodium channels. Commercially, quinine is also recognized as a key bitter and flavoring agent in tonic water.

The mechanism of quinine's antimalarial action involves its ability to disrupt the parasite's fundamental processes, specifically by blocking their capacity to create essential energy and proteins required for survival. This targeted action underscores its effectiveness as a parasiticidal agent. Achieving high purity, typically above 99%, is paramount for pharmaceutical applications, ensuring both efficacy and safety.

As with any potent pharmaceutical, the use of Quinine CAS 130-95-0 requires careful consideration of potential side effects and drug interactions. Common side effects can include headache, sweating, nausea, vomiting, and ringing in the ears. More serious, albeit less common, adverse reactions encompass severe allergic responses, skin conditions like Stevens-Johnson syndrome, blood disorders such as hemolytic anemia or thrombotic thrombocytopenic purpura, and cardiac rhythm abnormalities. It is crucial for medical professionals to assess a patient's full health profile, including any existing heart conditions, liver or kidney issues, or known allergies, before administration. The compound interacts with numerous other medications, particularly those affecting heart rhythm or metabolized by CYP3A4 enzymes, necessitating thorough professional evaluation.

For pharmaceutical companies and researchers, securing a reliable supply of high-quality Quinine CAS 130-95-0 is essential. Leading manufacturers and suppliers prioritize stringent quality control and Good Manufacturing Practices (GMP) to ensure the purity and consistency of this vital raw material. When looking to buy Quinine CAS 130-95-0, it is advisable to engage with reputable sources that can provide comprehensive product specifications and certificates of analysis. While the price of Quinine powder can vary based on purity, quantity, and market demand, investing in a trusted Quinine supplier guarantees a product suitable for sensitive pharmaceutical applications. For those seeking to purchase Quinine raw material in bulk, establishing a direct relationship with a proven Quinine manufacturer ensures long-term supply stability and competitive pricing.