Quinoline-2-carboxylic Acid, also widely known as Quinaldic Acid, with the Chemical Abstracts Service (CAS) number 93-10-7, stands as a versatile organic compound pivotal in various chemical processes. This brownish powder, characterized by its consistent purity of 99% minimum, is a key building block in the synthesis of complex organic molecules and plays a significant role in analytical chemistry.

Chemically, Quinoline-2-carboxylic Acid boasts the molecular formula C10H7NO2 and a molecular weight of 173.168 g/mol. Its physical properties include a boiling point of approximately 348.7±17.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3, and a melting point ranging from 156-158 °C. These precise specifications underscore its consistent quality and reliability for demanding applications. The compound is readily identifiable by its EINECS number 202-218-3.

One of the primary applications of Quinoline-2-carboxylic Acid is its utility as an organic intermediate. Its unique structural features, particularly the quinoline ring system and the carboxylic acid group, make it highly reactive and adaptable for numerous synthetic pathways. This makes it indispensable in the creation of pharmaceutical intermediates, agrochemicals, and specialty chemicals. Manufacturers rely on its consistent quality to ensure the integrity and efficacy of their downstream products.

Beyond its role in synthesis, Quinaldic Acid is also recognized for its use as a precipitant in analytical chemistry. It is effectively employed to detect and quantify various metal ions, including copper, iron, zinc, and uranium. The compound forms insoluble salts with these metals, enabling their precise determination. This analytical application highlights its importance in quality control and research laboratories worldwide.

Recent scientific advancements have also shed light on the potential biological activities of quinoline-2-carboxylic acid derivatives. While quinoline-4-carboxylic acid derivatives are well-known for their anti-inflammatory and analgesic properties, research indicates that structurally analogous esters and amides of quinoline-2-carboxylic acid can also be synthesized and exhibit similar pharmacological effects. Studies have demonstrated their potential as anti-inflammatory and analgesic agents, with comparative efficacy to standard drugs like diclofenac sodium. This exciting area of research suggests a promising future for Quinoline-2-carboxylic Acid as a foundational compound for developing new therapeutic agents, particularly in the realm of pain management and inflammation treatment. The synthetic methods for preparing these derivatives, typically involving the reaction of quinoline-2-carboxylic acid chloride with appropriate phenols or arylamines, are a testament to the compound's versatility in medicinal chemistry.

The synthesis of Quinoline-2-carboxylic Acid itself often involves the hydrolysis of N-benzoyl-2-hydrogen-2-cyanoquinoline, which is typically prepared from the reaction of benzoyl-potassium chloride-cyanide-quinoline in an aqueous medium. This established synthetic route ensures the production of high-purity material essential for various high-value applications.

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