(R)-3-Aminoazepan-2-one (CAS: 28957-33-7) stands as a pivotal chemical compound in the intricate landscape of pharmaceutical development. Recognized by its systematic chemical name, (3R)-3-aminoazepan-2-one, this compound plays a critical role as an intermediate in the synthesis of a variety of advanced therapeutic agents. It is also known by several synonyms, including D-2-aminohexano-6-lactam and D-Lysine lactam, reflecting its structural characteristics and historical nomenclature. With a precise molecular formula of C6H12N2O and a molecular weight of 128.17200, its specific chirality, denoted by (R), is crucial for its distinct biological activities and applications in asymmetric synthesis.

The physical and chemical properties of (R)-3-Aminoazepan-2-one are well-defined, ensuring its reliable performance in manufacturing processes. It typically appears as yellow crystals, although variations to a white powder form can be observed depending on purity and processing. Key physical characteristics include a density of 0.893g/cm³, a boiling point of 180.9ºC at 760 mmHg, and a flash point of 69.6ºC. Its refractive index is measured at 1.453, and it exhibits a melting point generally within the range of 97-101 °C. These parameters are essential for handling, processing, and quality control in pharmaceutical manufacturing environments.

Maintaining the integrity and effectiveness of (R)-3-Aminoazepan-2-one necessitates stringent quality control and proper storage. Our specifications demand a purity of greater than or equal to 97%, with an enantiomeric excess (EE) of greater than or equal to 98%, ensuring the desired stereospecificity critical for pharmaceutical applications. For optimal preservation, it should be stored in a cool, dry, and well-closed container, safeguarded from moisture, strong light, and excessive heat. Ideally, storage under an inert gas, such as nitrogen or argon, at temperatures between 2-8°C, is recommended to prevent degradation and maintain long-term stability.

The primary application of (R)-3-Aminoazepan-2-one lies in its indispensable role as an intermediate in the synthesis of several fluoroquinolone antibiotics. Most notably, it is a key precursor for Balofloxacin (CAS: 127294-70-6) and Besifloxacin hydrochloride (CAS: 405165-61-9). Balofloxacin is a broad-spectrum fluoroquinolone antibacterial agent used to treat various bacterial infections. Similarly, Besifloxacin hydrochloride is a potent ophthalmic fluoroquinolone antibiotic specifically used for bacterial conjunctivitis. Beyond these established uses, this compound is also a valuable research chemical, serving as an intermediate in the synthesis of bengamide E analogs and capuramycin and its analogs, explored for their antibacterial properties. Furthermore, it is employed in the development of β-oxocarboxamides, which show promise as antiviral agents, highlighting its versatility in drug discovery.

For pharmaceutical companies and research institutions seeking high-quality (R)-3-Aminoazepan-2-one, selecting a reliable manufacturer and supplier is paramount. Our commitment to excellence ensures that every batch meets the most rigorous industry standards, providing partners with the consistent quality they need for their critical applications. We offer competitive price structures and flexible packaging options, including 25kg cardboard drums or tailored solutions to meet specific customer requirements. To buy or purchase this essential intermediate, prospective clients are encouraged to contact us for detailed specifications and quotation. Our robust supply chain and dedication to product integrity make us a preferred choice for your chemical sourcing needs, facilitating the advancement of global health through superior pharmaceutical ingredients.