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Escitalopram, the active S-enantiomer of Citalopram, is a cornerstone in the treatment of depression and anxiety disorders. The purity and consistent supply of its key intermediates are therefore critical for pharmaceutical manufacturers. One such vital compound is 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile, identified by CAS number 103146-25-4, often referred to as Citadiol Base or Escitalopram Impurity E in some contexts. This article explores its significance in ensuring Escitalopram’s purity and the considerations for procurement professionals.
The synthesis of Escitalopram demands intermediates with exceptionally high purity to achieve the desired enantiomeric excess and minimize unwanted byproducts. Citadiol (CAS 103146-25-4) serves as a pivotal precursor, and its quality directly impacts the final API’s profile. Pharmaceutical companies looking to purchase this intermediate must prioritize suppliers who can consistently deliver material meeting stringent purity specifications, typically ≥98.0%. The physical characteristics, such as a white powder appearance, should also align with established standards.
For global pharmaceutical operations, identifying reliable manufacturers and suppliers of 103146-25-4 is a strategic imperative. Companies based in regions like China offer a competitive advantage, often providing a balance of quality and cost-effectiveness. When seeking to buy this intermediate, it is essential to perform thorough due diligence. This includes requesting comprehensive Certificates of Analysis (CoAs), understanding the supplier’s manufacturing processes, and, if possible, conducting site audits. Obtaining a detailed quote that clearly outlines specifications, payment terms, and delivery schedules is also crucial.
Furthermore, the availability and lead times for this intermediate can significantly influence production planning. Partnering with a supplier who maintains robust inventory levels or offers reliable custom synthesis services can mitigate supply chain risks. For procurement managers aiming to secure the best price and terms, building long-term relationships with trusted vendors is often the most effective strategy. Ensuring the consistent availability of high-quality Citadiol Base (CAS 103146-25-4) is fundamental to maintaining the integrity and market supply of Escitalopram.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
