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The Role of 17-Iodoandrosta-5,16-dien-3beta-ol in Abiraterone Acetate Synthesis

The pharmaceutical industry relies on a complex chain of chemical synthesis to produce life-saving medications. Among the crucial components in this chain are specialized intermediates, compounds that serve as foundational building blocks for Active Pharmaceutical Ingredients (APIs). One such vital intermediate is 17-Iodoandrosta-5,16-dien-3beta-ol, identified by its CAS number 32138-69-5. This article delves into its significance, particularly in the synthesis of Abiraterone Acetate, and highlights why sourcing this compound from a reputable pharmaceutical intermediate manufacturer is essential.

Understanding the Chemical Significance of 17-Iodoandrosta-5,16-dien-3beta-ol
17-Iodoandrosta-5,16-dien-3beta-ol is a steroid derivative characterized by an iodine atom at the 17-position and specific double bonds within its steroidal structure. Its unique chemical architecture makes it an ideal precursor for targeted pharmaceutical synthesis. The compound's primary application is as a key intermediate in the multi-step synthesis of Abiraterone Acetate, a highly effective drug used to treat advanced prostate cancer. The specific arrangement of functional groups within this intermediate is crucial for facilitating the necessary chemical transformations to yield the final API.

The Synthesis Pathway: From Intermediate to API
The transformation of 17-Iodoandrosta-5,16-dien-3beta-ol into Abiraterone Acetate involves sophisticated organic chemistry. While the exact proprietary routes vary, the iodine at the 17-position often serves as a leaving group or a point of attachment for further functionalization, such as coupling reactions. The steroidal backbone is carefully modified to achieve the desired pharmacological activity. For R&D scientists and process chemists, the quality of the starting intermediate directly impacts the yield, purity, and overall feasibility of the synthesis. This is why securing high-purity 17-Iodoandrosta-5,16-dien-3beta-ol is a non-negotiable aspect of drug development.

Why Partner with a Reliable Supplier?
When you buy 17-Iodoandrosta-5,16-dien-3beta-ol for pharmaceutical applications, you are not just purchasing a chemical; you are investing in the quality and compliance of your final product. A trusted 17-Iodoandrosta-5,16-dien-3beta-ol supplier ensures:

  • Consistent Purity: High purity levels (typically ≥99%) minimize unwanted side reactions and impurities in the final API, crucial for regulatory approval and patient safety.
  • Reliable Supply: A stable manufacturing partner in China guarantees consistent availability, preventing costly delays in production schedules.
  • Technical Documentation: Provision of comprehensive documentation, including Certificates of Analysis (CoA), ensuring transparency and traceability.
  • Competitive Pricing: Efficient manufacturing processes allow for cost-effective procurement, contributing to the overall economic viability of API production.

From Intermediate to Innovation: Our Commitment
As a leading 17-Iodoandrosta-5,16-dien-3beta-ol manufacturer, we are dedicated to supporting the pharmaceutical industry by providing this critical intermediate with the highest standards of quality and consistency. Our advanced synthesis capabilities and stringent quality control measures ensure that our product meets the exacting requirements for Abiraterone Acetate synthesis and other complex pharmaceutical applications. We invite procurement managers and scientists to inquire about our offerings and explore how our reliable supply can benefit your development pipeline.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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