The landscape of drug discovery is constantly evolving, with new molecular entities and therapeutic targets emerging regularly. At the heart of this innovation are advanced chemical building blocks that enable medicinal chemists to construct complex and highly specific molecules. 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine (CAS: 1034667-22-5) stands out as one such critical intermediate. Its intricate structure, featuring a fluorinated pyrazolo[3,4-b]pyridine core, offers unique reactivity and physiochemical properties that are highly valued in pharmaceutical research and development.

This compound serves as a cornerstone in the synthesis of various bioactive molecules. Its inclusion in a synthetic route can impart desirable characteristics such as improved metabolic stability, enhanced target binding affinity, and optimized pharmacokinetic profiles. The presence of the fluorine atom, in particular, can significantly influence lipophilicity and binding interactions, making it a strategic choice for drug designers. Researchers looking to buy pharmaceutical intermediates for novel therapeutic agents often prioritize compounds like this for their versatility and potential to unlock new pharmacological avenues.

One of the most prominent applications of 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine is its role as an intermediate in the synthesis of Vericiguat. Vericiguat is a soluble guanylate cyclase stimulator used to treat symptomatic chronic heart failure. The reliable supply of high-purity intermediates like CAS 1034667-22-5 is therefore directly linked to the availability of essential medicines. As a dedicated pharmaceutical intermediate supplier, we understand the critical nature of this supply chain and ensure that our product meets rigorous quality specifications, typically with an assay of ≥95%. This commitment makes us a go-to source for those needing to purchase this specific intermediate.

For those in the pharmaceutical industry, engaging with manufacturers that offer comprehensive support, from technical data to flexible ordering, is key. We provide detailed product information, competitive pricing, and efficient global shipping solutions. Whether you are a researcher seeking small quantities for exploratory studies or a production manager planning for large-scale synthesis, we are equipped to meet your demands. Contact us to learn more about purchasing 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine and how we can support your drug discovery endeavors.