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In the intricate world of Active Pharmaceutical Ingredient (API) synthesis, the quality and reliability of chemical intermediates are non-negotiable. One such vital compound is 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (CAS 100331-89-3). As a key building block, this intermediate is instrumental in the creation of various therapeutic agents, particularly those targeting respiratory conditions. For procurement professionals and R&D scientists, understanding its chemical properties and securing a dependable supply chain from a reputable manufacturer is crucial.
Chemical Profile and Properties
8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, identified by its CAS number 100331-89-3, typically presents as an off-white to pale beige solid powder. Its molecular formula is C18H14BrNO3, with a molecular weight of approximately 372.21 g/mol. The compound's chemical structure, featuring a quinolinone core with a bromoacetyl group and a benzyloxy substituent, makes it highly reactive and suitable for complex organic transformations. Key properties to note when you buy this chemical include its solubility (often in solvents like chloroform) and stability. Ensuring it remains stable under recommended storage conditions is vital for maintaining its efficacy for downstream synthesis.
Applications in Pharmaceutical Manufacturing
The primary application of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline lies in its role as a pharmaceutical intermediate. It is particularly significant in the synthesis of phenylethanolamine derivatives that act as beta-2 adrenoreceptor agonists. These agonists are critical components in medications designed to treat conditions like COPD and asthma, by relaxing airway muscles. Specifically, it is a key intermediate in the synthesis of Indacaterol. For companies looking to purchase this intermediate, consistency in batch-to-batch quality is paramount to ensure the safety and efficacy of the final API. Sourcing from a trusted supplier in China can provide a cost-effective solution without compromising on quality.
Sourcing Considerations for Procurement Managers
When a pharmaceutical company needs to acquire 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, the procurement process requires careful due diligence:
By carefully considering these factors and choosing a reputable pharmaceutical intermediate supplier, organizations can ensure the quality and efficiency of their API manufacturing processes, ultimately contributing to the development of life-improving medications.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
