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At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to supplying essential components that drive pharmaceutical innovation. Among these, disintegrants play an indispensable role in the effective delivery of medications. This article focuses on Croscarmellose Sodium (CCS), a leading superdisintegrant, and elucidates its critical importance in pharmaceutical tablet formulations.
The efficacy of a tablet is intrinsically linked to its ability to disintegrate rapidly after administration. Disintegrants are excipients incorporated into tablet formulations to promote this breakdown, ensuring that the active pharmaceutical ingredient (API) is released efficiently for absorption. Croscarmellose Sodium, a cross-linked polymer of carboxymethyl cellulose, excels in this role due to its superior water absorption and swelling capabilities. These properties enable it to act as a highly effective superdisintegrant.
The mechanism by which Croscarmellose Sodium operates involves rapid hydration and swelling. Upon exposure to moisture in the gastrointestinal tract, CCS particles expand significantly, generating an internal force that breaks apart the tablet matrix. This process, often enhanced by capillary action ('wicking'), ensures that the tablet disintegrates into smaller particles swiftly. This rapid disintegration is crucial for achieving optimal drug bioavailability and for APIs that require quick dissolution for therapeutic effect.
The advantages of using Croscarmellose Sodium in pharmaceutical tablet formulations are numerous. It offers excellent disintegration efficiency even at low concentrations, making it a cost-effective choice. Furthermore, its compatibility with a wide range of APIs and other excipients allows for greater formulation flexibility. Whether used in direct compression or granulation processes, CCS consistently provides reliable disintegration performance. The choice of superdisintegrant is critical, and CCS's balanced properties make it a preferred option for many pharmaceutical developers.
NINGBO INNO PHARMCHEM CO.,LTD. provides pharmaceutical-grade Croscarmellose Sodium, adhering to the highest quality standards. By leveraging the exceptional capabilities of this pharmaceutical excipient, manufacturers can ensure their products disintegrate effectively, leading to improved patient outcomes and enhanced medication performance.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
