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In the intricate world of pharmaceutical synthesis, specific chemical intermediates play pivotal roles as building blocks for complex APIs. One such essential compound is 5-(2-chloroethyl)-2,3-dihydro-1-benzofuran (CAS: 943034-50-2). For R&D scientists and formulation specialists, understanding the application and sourcing of this intermediate is key to ensuring successful drug manufacturing. This article delves into the importance of this compound and how to best procure it.
Understanding the Intermediate: Properties and Synthesis
5-(2-chloroethyl)-2,3-dihydro-1-benzofuran is a white crystalline powder, known for its high purity, typically assaying at ≥98.0% by HPLC. Its molecular formula is C10H11ClO, with a molecular weight of 182.65. The compound's utility stems from its specific chemical structure, making it an ideal precursor for further chemical transformations.
Critical Application: Darifenacin Synthesis
The primary significance of 5-(2-chloroethyl)-2,3-dihydro-1-benzofuran lies in its role as a crucial intermediate in the synthesis of Darifenacin and its hydrobromide salt. Darifenacin is a medication used to treat urinary incontinence by relaxing bladder muscles. The introduction of the chloroethyl group and the benzofuran ring system in this intermediate are vital for constructing the final Darifenacin molecule.
For pharmaceutical companies engaged in the production of Darifenacin, securing a reliable supply of high-quality 5-(2-chloroethyl)-2,3-dihydro-1-benzofuran is non-negotiable. This ensures consistent reaction yields, purity of the final API, and adherence to strict regulatory standards. When seeking to purchase this chemical, keywords like 'buy Darifenacin intermediate' or '5-(2-chloroethyl)-2,3-dihydro-1-benzofuran price' can help locate qualified suppliers.
Sourcing and Partnership Opportunities
As a key pharmaceutical intermediate supplier, manufacturers such as NINGBO INNO PHARMCHEM CO.,LTD. offer this compound in bulk quantities and support contract manufacturing. Partnering with such a manufacturer provides several benefits:
For R&D scientists and procurement teams, identifying a trusted manufacturer for 5-(2-chloroethyl)-2,3-dihydro-1-benzofuran is a significant step towards streamlined API production. By focusing on suppliers with proven expertise and commitment to quality, pharmaceutical companies can ensure the successful development and manufacturing of vital medications.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
