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In the intricate world of biochemical research, understanding enzyme mechanisms is paramount. p-Aminophenyl Arsenoxide (CAS 1122-90-3) stands out as a crucial reagent for scientists investigating enzyme inhibition, particularly within the realm of 2-oxoacid dehydrogenase multienzyme complexes. As a leading supplier of fine chemicals, understanding the precise applications of compounds like p-Aminophenyl Arsenoxide allows us to better serve the scientific community.
The efficacy of p-Aminophenyl Arsenoxide as an enzyme inhibitor stems from its chemical structure, which features a trivalent arsenic atom. This arsenic center exhibits a strong affinity for sulfhydryl (-SH) groups, commonly found in cysteine residues within enzyme active sites. When vicinal dithiols – two thiol groups in close proximity – are present, as in the lipoic acid cofactor of dehydrogenase complexes, p-Aminophenyl Arsenoxide can form stable cyclic dithioarsinite structures. This covalent modification effectively inactivates the enzyme by blocking its catalytic activity. Researchers often buy p-Aminophenyl Arsenoxide to study these specific interactions, providing critical insights into enzyme kinetics and function.
For instance, the pyruvate dehydrogenase complex, a key player in cellular energy metabolism, contains lipoic acid. Studies have demonstrated that p-Aminophenyl Arsenoxide can readily inhibit this complex by forming a stable adduct with its lipoic acid cofactor, significantly reducing or halting the enzyme's activity. This precise targeting makes p-Aminophenyl Arsenoxide an invaluable tool for researchers aiming to elucidate metabolic pathways and develop targeted enzyme inhibitors. As a reputable manufacturer and supplier, we ensure the highest purity for p-Aminophenyl Arsenoxide, enabling accurate and reliable research outcomes. If you are looking to buy this specialized chemical for your enzyme inhibition studies, consider our consistent supply and quality assurance.
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