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The pharmaceutical industry constantly seeks innovative molecules and efficient synthesis routes to develop life-saving and life-enhancing medications. At the heart of this endeavor are chemical intermediates – the crucial building blocks that enable the creation of complex active pharmaceutical ingredients (APIs). One such vital intermediate is trans-1-Cinnamylpiperazine, identified by CAS number 87179-40-6.
trans-1-Cinnamylpiperazine plays a pivotal role in several key areas of pharmaceutical synthesis. Its most well-documented application is as a precursor for flunarizine hydrochloride. Flunarizine, a diphenylmethylpiperazine derivative, is a selective calcium channel blocker widely prescribed for the prevention of migraine and the treatment of vertigo. The synthesis pathway from trans-1-Cinnamylpiperazine to flunarizine hydrochloride requires specific reaction conditions and high-purity starting materials, making the reliability of the intermediate paramount.
Beyond its established use, trans-1-Cinnamylpiperazine is also being explored in the synthesis of novel therapeutic agents. Research indicates its utility in creating bile acid piperazinyl derivatives. These compounds have demonstrated potential pro-apoptotic properties, a mechanism of action highly sought after in cancer therapy. This opens up new avenues for drug discovery and development, where trans-1-Cinnamylpiperazine serves as a versatile scaffold for creating drug candidates with enhanced efficacy and targeted action.
For research scientists and product formulators, understanding the chemical properties and reactivity of trans-1-Cinnamylpiperazine is essential. Its structure, featuring both a piperazine ring and a cinnamyl group, allows for various chemical modifications, making it a valuable tool in medicinal chemistry. The ability to reliably purchase this compound from reputable manufacturers is therefore critical for the progression of research projects and the scale-up of potential drug candidates.
When looking to purchase trans-1-Cinnamylpiperazine, it is advisable to work with manufacturers who can guarantee high purity (typically ≥98%) and consistent batch quality. Factors such as its appearance (often a clear to light yellow liquid or solid), melting point (39-44°C), and boiling point (129°C at 1 mmHg) are important specifications to verify. Companies like NINGBO INNO PHARMCHEM CO.,LTD. stand as leading suppliers in China, offering this intermediate for various applications, from R&D to commercial production. Inquiring about bulk quantities and competitive pricing from such suppliers can streamline your procurement process for this indispensable pharmaceutical intermediate.
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A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
