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The Role of Z-Tyr(Bzl)-OH in Advanced Peptide Synthesis

The synthesis of complex peptides is a cornerstone of pharmaceutical research and development, and the precise use of protected amino acid building blocks is indispensable. Z-Tyr(Bzl)-OH, bearing the CAS number 16677-29-5, is a prime example of such a critical reagent. Its unique structural features, particularly the protective groups, enable chemists to construct intricate peptide sequences with high fidelity.

Z-Tyr(Bzl)-OH is a derivative of L-tyrosine where the alpha-amino group is protected by a benzyloxycarbonyl (Z) moiety and the side-chain phenolic hydroxyl group is protected by a benzyl (Bzl) ether. This dual protection is vital for solid-phase peptide synthesis (SPPS). During the coupling step, the Z-group prevents self-reaction of the amino group, while the Bzl-group shields the reactive hydroxyl function of tyrosine. This allows for the selective formation of peptide bonds, ensuring that only the intended amino acids are linked in the correct sequence.

For scientists and procurement managers, sourcing high-purity Z-Tyr(Bzl)-OH is a priority. When looking to buy Z-Tyr(Bzl)-OH, identifying a reliable manufacturer or supplier is paramount. Companies that specialize in amino acid derivatives and peptide reagents offer products that meet stringent quality standards, often specifying purity levels greater than 98%. The CAS number 16677-29-5 is the key identifier for this specific compound.

The molecular weight of Z-Tyr(Bzl)-OH is approximately 405.44 g/mol, and it typically presents as a white crystalline powder. These properties are consistent across reputable suppliers. For B2B operations, understanding the Z-Tyr(Bzl)-OH price is a significant factor in budget planning. Many chemical suppliers, especially those in China, offer competitive pricing for bulk orders and Z-Tyr(Bzl)-OH wholesale quantities, making it more accessible for large-scale peptide production.

The utility of Z-Tyr(Bzl)-OH extends beyond just preventing side reactions; it also impacts the solubility and handling characteristics of the amino acid derivative, which are important considerations in automated peptide synthesizers. Its stability under various coupling conditions makes it a preferred choice for many peptide synthesis protocols.

In summary, Z-Tyr(Bzl)-OH (CAS 16677-29-5) is a foundational component for advanced peptide synthesis. By carefully selecting a reputable manufacturer or supplier and understanding the product's properties and availability, research institutions and pharmaceutical companies can ensure the successful and efficient production of high-quality peptides. To acquire this essential reagent, initiating inquiries for quotes and exploring wholesale options from trusted chemical providers is the most effective approach.

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