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(S)-3-Amino-1-N-Boc-piperidine (CAS 625471-18-3): A Key Pharmaceutical Intermediate

In the dynamic realm of pharmaceutical development and advanced chemical synthesis, the demand for high-purity, specialized building blocks is ever-increasing. Among these crucial compounds, (S)-3-Amino-1-N-Boc-piperidine, identified by its CAS number 625471-18-3, stands out as a significant pharmaceutical intermediate. This compound, also known by synonyms such as tert-butyl (3S)-3-aminopiperidine-1-carboxylate, plays a pivotal role in creating complex molecular structures vital for next-generation therapeutics.


Chemically, (S)-3-Amino-1-N-Boc-piperidine possesses a molecular formula of C10H20N2O2 and a molecular weight of 200.27800 g/mol. Its unique stereochemistry, indicated by the '(S)' designation, is critical for pharmaceutical applications where chirality often dictates efficacy and safety. Key physical and chemical properties include a predicted boiling point of 277.3±33.0 °C and a flash point of 122℃. The compound typically appears as a colorless to yellow gum or semi-solid, exhibiting a density of 1.02 and a refractive index between 1.4690 and 1.4730. Its specific rotation is noted as -28.5 º (c=1, DMF), with an optical activity of [α]/D +32.0±3°, c = 1 in DMF, underscoring its chiral purity. It is soluble in dimethylsulfoxide and demonstrates stability at room temperature when stored in closed containers under normal conditions, though it is recognized as air sensitive.


The primary utility of (S)-3-Amino-1-N-Boc-piperidine lies in its extensive use as a general-purpose reagent and a key pharmaceutical intermediate. Researchers and drug developers highly value it for its versatility in synthesizing a wide array of active pharmaceutical ingredients (APIs). A notable application involves its use in preparing selective noncovalent inhibitors of bacterial cysteine protease IdeS, which is crucial for combating bacterial infections. Furthermore, it serves as a critical reference compound in scientific studies, particularly for determining the absolute configuration of enantiomers, ensuring precision and reproducibility in chemical research.


NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality (S)-3-Amino-1-N-Boc-piperidine (CAS 625471-18-3), ensuring it meets rigorous industry standards with a minimum purity of 95%. Our commitment to excellence guarantees that our clients receive reliable and consistent materials essential for their research and manufacturing processes. We understand the critical importance of purity and consistency in pharmaceutical synthesis and strive to be a dependable supplier for global pharmaceutical and chemical industries.


For those looking to buy or purchase this essential compound, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price and various packaging options, from grams to kilograms, to accommodate diverse project scales. As a reputable manufacturer and distributor, we provide comprehensive support, ensuring a seamless procurement experience. Our team is ready to assist with inquiries regarding product specifications, availability, and logistics, facilitating your access to high-grade chemical intermediates for your innovative projects.

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