(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine (CAS 132335-44-5) stands as a critical pharmaceutical intermediate, indispensable in the synthesis of complex active pharmaceutical ingredients (APIs). With its unique stereochemical configuration, specifically the (S)-enantiomer, this compound plays a pivotal role in ensuring the efficacy and safety of downstream pharmaceutical products. Its precise chemical structure, characterized by a dimethylamino group, a hydroxyl group, and a thienyl moiety, contributes to its specific reactivity and utility in organic synthesis, particularly within the pharmaceutical sector.

This advanced chemical is also known by several synonyms, including (1S)-3-(dimethylamino)-1-thiophen-2-ylpropan-1-ol and (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol, highlighting its structural and functional attributes. The molecular formula of C9H15NOS and a molecular weight of 185.28600 further define its composition. As a white powder, it exhibits a distinct set of physical and chemical properties crucial for its handling and application. These include a density of 1.111g/cm3, a boiling point of approximately 290ºC, a melting point ranging from 78-80ºC, and a flash point of 129ºC. Its refractive index is measured at 1.553. For optimal preservation, this compound should be stored in a cool and dry place, away from strong light and heat, ideally sealed in the dark at 2-8°C, to maintain its integrity and high quality over time.

Quality assurance is paramount for pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. ensures that (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine consistently meets stringent specifications. Our product boasts a purity level of ≥98.0%, with rigorous controls on impurities such as water content (≤0.5%), loss on drying (≤0.5%), sulphated ash (≤0.1%), and heavy metal content (≤20ppm). A single impurity limit of ≤0.1% underscores our commitment to providing a product of exceptional quality, essential for sensitive pharmaceutical applications. This high level of purity is vital for achieving optimal yields and desired product profiles in subsequent synthesis steps.

The primary application of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine lies in its role as a key intermediate in the synthesis of Duloxetine hydrochloride (CAS: 136434-34-9). Duloxetine is a widely used medication, primarily prescribed for the treatment of major depressive disorder, generalized anxiety disorder, neuropathic pain, and fibromyalgia. The precise enantiomeric purity of our intermediate is crucial for the stereoselective synthesis of Duloxetine, ensuring the production of the therapeutically active form and minimizing impurities. This makes our product indispensable for pharmaceutical companies engaged in the production of this vital antidepressant and pain management drug.

Safety in handling and processing this chemical is emphasized. While it presents certain hazards, including causing skin irritation (H315) and serious eye irritation (H319), and potentially being harmful if swallowed (H302), appropriate precautionary measures can mitigate risks. These include wearing protective gloves, eye protection, and face protection (P280), and ensuring thorough washing after handling (P264). In case of skin contact, wash thoroughly with water (P302+P352); for eye contact, rinse cautiously with water for several minutes (P305+P351+P338). Adhering to these safety guidelines is essential for personnel working with this material.

As a leading manufacturer and supplier of high-quality chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing superior (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine. We maintain robust production capabilities and a stringent quality control system to ensure the consistent delivery of products that meet global pharmaceutical standards. Whether you are looking to buy in bulk or require specific quantities, our competitive price structure and efficient logistics ensure a seamless procurement experience. We are equipped to handle various packaging requirements, including 25kg cardboard drums, or tailor packaging to customer-specified needs. For those seeking to purchase this essential intermediate with confidence, our team is ready to provide comprehensive technical support and assist with all your requirements. Choose NINGBO INNO PHARMCHEM CO.,LTD. for reliable supply and unwavering commitment to quality in your pharmaceutical synthesis endeavors.