For professionals in the chemical and pharmaceutical industries, a deep understanding of chemical intermediates is crucial for successful product development and efficient manufacturing. 4-Bromo-1-fluoro-2-nitrobenzene (CAS 364-73-8) is a prominent example of such an intermediate, valued for its specific chemical structure and reactivity. This article explores its key physical and chemical properties, offering insights that are vital for procurement managers, research scientists, and formulation chemists.

Unpacking the Molecular Structure and Properties

4-Bromo-1-fluoro-2-nitrobenzene, with the molecular formula C6H3BrFNO2 and a molecular weight of approximately 220.0 g/mol, presents a unique combination of functional groups on a benzene ring. The presence of bromine, fluorine, and a nitro group dictates its chemical behavior.

Physical Characteristics:

• Appearance: Typically observed as a light yellow liquid.
• Melting Point: Reported around 18-19 °C, which means it is a solid at lower temperatures and a liquid under ambient conditions. This characteristic is important for handling and storage.
• Boiling Point: Approximately 257.5 °C at 760 mmHg, indicating a relatively high boiling point and low volatility under standard conditions.
• Density: Around 1.8 ± 0.1 g/cm³ at 25 °C, suggesting it is a relatively dense liquid.
• Refractive Index: Typically around 1.580, a useful parameter for quality control.
• Flash Point: Approximately 109.5 ± 21.8 °C, providing an indication of its flammability.
• Vapor Pressure: Very low at 25 °C (0.0 ± 0.5 mmHg), contributing to its handling safety.

Chemical Reactivity and Stability:

The combination of electron-withdrawing groups (nitro and fluorine) and a halogen (bromine) makes the benzene ring electron-deficient. This influences its reactivity, making it amenable to nucleophilic aromatic substitution reactions. The bromine atom is readily displaced, and the nitro group can be reduced. Its stability is generally good under recommended storage conditions (cool, ventilated place), but like many nitroaromatic compounds, it should be handled with care.

Synthesis Pathways

While specific proprietary synthesis methods vary among manufacturers, common routes to producing 4-Bromo-1-fluoro-2-nitrobenzene involve sequential halogenation and nitration reactions on fluorobenzene or bromobenzene derivatives. Alternatively, starting from a pre-functionalized nitrobenzene and introducing the halogens can also be employed. The exact pathway chosen by a manufacturer depends on factors like raw material availability, cost-effectiveness, and the desired purity levels.

Ensuring Quality: Specifications and Beyond

For R&D scientists and procurement professionals, understanding the product specifications is key. A typical specification for 4-Bromo-1-fluoro-2-nitrobenzene includes an assay of ≥98.0%. This high purity is critical for ensuring predictable reaction outcomes and minimizing side products in downstream applications, especially in the pharmaceutical and agrochemical industries. When you buy 4-Bromo-1-fluoro-2-nitrobenzene, always verify the assay and request relevant documentation like Certificates of Analysis (CoA).

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier committed to providing chemical intermediates that meet stringent quality standards. We understand the importance of precise properties and reliable synthesis for our B2B clients. If you are seeking a dependable source for 4-Bromo-1-fluoro-2-nitrobenzene, understanding these properties will help you make informed decisions about its suitability for your applications and value the expertise of your chosen chemical partner.

By comprehending the science behind 4-Bromo-1-fluoro-2-nitrobenzene, researchers and purchasers can better leverage its potential and ensure successful chemical synthesis outcomes.