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5-(Ethylthio)-1H-tetrazole (CAS 89797-68-2) is a fascinating heterocyclic compound with a unique structure that underpins its valuable applications in various chemical industries. As a manufacturer deeply involved in its production, we understand the intricate science behind this molecule and are pleased to share insights into its properties and synthesis.
Chemical Structure and Properties
The molecule features a five-membered tetrazole ring, a stable aromatic system containing four nitrogen atoms, substituted with an ethylthio (-SCH2CH3) group. This functional group imparts specific reactivity and physical characteristics. Typically observed as a white powder, its molecular formula is C3H6N4S, with a molecular weight of approximately 130.17 g/mol. Key physical properties include a melting point in the range of 85-89°C (though some sources indicate a slightly lower range of 72-80°C, emphasizing the importance of purity specification). Its solubility in various solvents is a crucial factor for its use in synthetic processes. A high assay, typically 99%min, ensures its suitability for demanding applications in pharmaceutical and agrochemical synthesis.
Synthesis Routes: From Raw Materials to High-Purity Product
The synthesis of 5-(Ethylthio)-1H-tetrazole commonly involves the reaction of ethylthiocyanate with sodium azide. This is often carried out under specific conditions, such as using phase-transfer catalysis, which facilitates the reaction between reactants in different phases, improving yield and efficiency. The choice of solvent (e.g., water/toluene mixtures) and reaction temperature are critical parameters that a skilled manufacturer meticulously controls to optimize the cycloaddition process. Alternative methods might employ different solvent systems, like DMF, though these can sometimes lead to lower yields. For industrial-scale production, process optimization focusing on cost-effectiveness, environmental impact, and achieving the desired high purity is paramount. As a manufacturer, our focus is on refining these synthesis routes to consistently deliver a premium product.
Applications Driven by Structure
The combination of the tetrazole ring and the ethylthio moiety makes 5-(Ethylthio)-1H-tetrazole an effective intermediate for synthesizing complex molecules. Its role as a protective agent and activator in DNA/RNA synthesis, and its utility in creating novel pharmaceuticals and pesticides, are direct consequences of its structural design. Understanding this science allows us to better serve our clients by providing a chemical tailored for their specific, high-value applications. If you are looking to buy this compound, partnering with an experienced manufacturer ensures you receive a product backed by sound chemical expertise.
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