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The construction of peptides, whether for therapeutic applications, research tools, or biochemical studies, is a highly precise scientific endeavor. At the heart of this process are amino acids, and specifically, protected amino acid derivatives like L-Glutamic acid gamma-tert-butyl ester (H-Glu-OtBu). NINGBO INNO PHARMCHEM CO.,LTD. specializes in the synthesis and supply of such critical components, understanding their scientific significance for researchers worldwide.
H-Glu-OtBu, also known as L-Glutamic acid gamma-tert-butyl ester, with the CAS number 2419-56-9, is a derivative of the naturally occurring amino acid glutamic acid. The 'OtBu' (tert-butyl ester) group is strategically placed on the gamma-carboxyl side chain. This protective group is essential in peptide synthesis because it prevents the side chain carboxyl group from participating in unwanted peptide bond formation or other side reactions during the controlled assembly of amino acid residues. Its molecular weight is approximately 203.2 g/mol, and its chemical formula is C9H17NO4.
The efficacy of a peptide drug or a synthesized peptide sequence is directly correlated with the fidelity of its synthesis. Therefore, the purity and reactivity of each amino acid building block, including H-Glu-OtBu, are paramount. Researchers and chemists who seek to buy H-Glu-OtBu are looking for a product that guarantees consistent performance in solid-phase peptide synthesis (SPPS) or solution-phase methods. As a manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. focuses on delivering precisely this: a scientifically sound product backed by rigorous quality control. Our position as a supplier in China allows us to offer competitive pricing for this essential chemical.
Understanding the chemical stability and reactivity profile of H-Glu-OtBu is crucial for chemists planning their synthesis strategies. The tert-butyl ester is known for its stability under common coupling conditions used in peptide synthesis, such as those employing carbodiimides (e.g., DCC, DIC) and activating agents (e.g., HOBt, HATU). Crucially, it can be readily cleaved using moderate acidic conditions (e.g., trifluoroacetic acid, TFA) along with other acid-labile protecting groups at the final stage of peptide assembly.
For any organization involved in advanced chemical synthesis, NINGBO INNO PHARMCHEM CO.,LTD. is a reliable partner. We provide high-quality H-Glu-OtBu and are ready to assist with bulk orders and inquiries. If you are looking to purchase L-Glutamic acid gamma-tert-butyl ester, consider our expertise and dedication to scientific excellence. Contact us today to learn more about our product offerings and how we can support your critical research and manufacturing needs.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
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3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
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