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At NINGBO INNO PHARMCHEM CO.,LTD., we delve into the intricate science behind the pharmaceutical ingredients we supply. Lapatinib Ditosylate Monohydrate is a prime example of a sophisticated molecule designed for targeted therapeutic intervention. This article will explore its chemical nature, mechanism of action, and its importance in the pharmaceutical landscape.
Lapatinib Ditosylate Monohydrate is classified as a small molecule tyrosine kinase inhibitor. Its chemical structure is complex, with the formula C86H86Cl2F2N8O21S6. The product boasts a high purity of over 99%, ensuring its efficacy and safety for pharmaceutical applications. As a powder, it is typically yellow in color and requires specific storage conditions, often under an inert gas like nitrogen or argon at 2-8°C, to maintain its integrity and potency.
The core therapeutic value of Lapatinib Ditosylate Monohydrate lies in its ability to inhibit receptor tyrosine kinases (RTKs), specifically ErbB-1 and ErbB-2. These RTKs are often overexpressed in various cancers, including a significant percentage of breast cancers. By binding to the intracellular ATP-binding site of these receptors, Lapatinib Ditosylate Monohydrate prevents their autophosphorylation and the subsequent activation of downstream signaling cascades that promote cell proliferation, survival, and metastasis. This makes it a critical agent in the Lapatinib Ditosylate Monohydrate applications for specific cancer types.
Understanding the pharmacokinetics is also crucial. Lapatinib Ditosylate Monohydrate is absorbed incompletely and variably after oral administration. It undergoes extensive metabolism, primarily by CYP3A4 and CYP3A5 enzymes. It is highly protein-bound, meaning it largely circulates in the bloodstream bound to proteins. Elimination occurs predominantly via the feces. The drug's half-life can increase with repeated dosing, reaching a steady state that provides an effective half-life of approximately 24 hours.
For research institutions and pharmaceutical companies looking to procure high-quality compounds, NINGBO INNO PHARMCHEM CO.,LTD. offers reliable sourcing for Lapatinib Ditosylate Monohydrate. We understand the importance of consistent quality and timely delivery for critical pharmaceutical intermediates. When considering the purchase of Lapatinib Ditosylate Monohydrate, our team can provide detailed specifications and support.
The development and availability of compounds like Lapatinib Ditosylate Monohydrate underscore the progress in targeted cancer therapies. As a leading Lapatinib Ditosylate Monohydrate manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to these advancements, offering crucial ingredients for research and treatment worldwide.
Manufacturing Facilities
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to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
