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Methyl 2-iodobenzoate (CAS 610-97-9) is a fascinating molecule with a distinct set of chemical properties that make it a cornerstone in many organic synthesis pathways. Its structure, featuring an iodine atom positioned adjacent to the ester group on the benzene ring, dictates its reactivity, particularly in metal-catalyzed cross-coupling reactions.
The physical state of methyl 2-iodobenzoate is typically described as a crystalline or flaky powder, often appearing white. Its solubility profile is also noteworthy; it is generally insoluble in water but readily dissolves in common organic solvents like chloroform and ethyl acetate, facilitating its use in a variety of reaction media. The compound's melting point is around 64°C, and its boiling point is approximately 149-150 °C at 10 mmHg, indicating its moderate volatility.
Understanding the methyl 2-iodobenzoate synthesis is key to appreciating its availability and cost. The most common route involves the esterification of 2-iodobenzoic acid. This reaction typically uses an acid catalyst, such as sulfuric acid, and methanol. The methyl 2-iodobenzoate synthesis requires careful temperature control to maximize yield and minimize side reactions. Researchers continually refine these methyl 2-iodobenzoate synthesis protocols to enhance purity and reduce environmental impact, often focusing on atom-economical pathways.
The chemical reactivity of methyl 2-iodobenzoate is largely attributed to the carbon-iodine bond, which is weaker and more polarizable than carbon-bromine or carbon-chlorine bonds. This makes it an excellent substrate for palladium-catalyzed cross-coupling reactions, allowing for the formation of new carbon-carbon bonds. These methyl 2-iodobenzoate applications are fundamental in building complex molecular architectures, particularly in the pharmaceutical industry for API synthesis and in the creation of advanced materials. Its role in facilitating these transformations underscores its importance in modern synthetic chemistry.
For chemists and manufacturers, a thorough understanding of the chemical properties and methyl 2-iodobenzoate synthesis is vital for effective utilization. Whether for laboratory research or industrial-scale production, the consistent availability of high-purity methyl 2-iodobenzoate from reliable sources like NINGBO INNO PHARMCHEM CO.,LTD. ensures the success of demanding chemical projects.
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