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Pirfenidone powder is a remarkable pharmaceutical compound celebrated for its dual action as a potent antifibrotic and anti-inflammatory agent. Understanding the intricate pirfenidone mechanism of action anti-fibrotic is key to appreciating its therapeutic value, particularly in conditions like idiopathic pulmonary fibrosis (IPF).
At the cellular level, Pirfenidone works by modulating several key fibrogenic pathways. It actively inhibits the production of crucial pro-fibrotic cytokines, such as transforming growth factor-beta 1 (TGF-β1), which are central to the excessive deposition of extracellular matrix characteristic of fibrosis. Additionally, Pirfenidone suppresses the proliferation of fibroblasts, the cells responsible for producing this matrix, thereby directly combating the fibrotic process.
The pirfenidone anti-inflammatory properties are equally significant. Chronic inflammation often drives and exacerbates fibrotic changes. Pirfenidone helps to mitigate this by downregulating the expression of pro-inflammatory mediators like tumor necrosis factor-alpha (TNF-α) and interleukins. This dual action—addressing both inflammation and fibrosis—makes it a comprehensive therapeutic agent.
This scientific understanding also underpins its emerging applications beyond IPF. For instance, in the context of renal tubulointerstitial fibrosis and hypertension-induced myocardial fibrosis, Pirfenidone's ability to reduce inflammation and inhibit fibroblast activity is crucial. These effects help to preserve organ function and prevent irreversible tissue damage.
The ongoing research into advanced drug delivery systems, such as nanostructured lipid carriers for Pirfenidone pulmonary delivery, aims to further leverage these mechanisms. By ensuring efficient drug concentration at the target site, these delivery systems enhance the therapeutic outcomes, allowing the potent anti-fibrotic and anti-inflammatory actions of Pirfenidone to be fully realized.
The scientific community continues to explore the full spectrum of Pirfenidone's capabilities, solidifying its reputation as a vital pharmaceutical raw material with broad therapeutic potential in managing fibrotic and inflammatory diseases.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
