For professionals in chemistry and related fields, a deep understanding of the compounds they work with is essential. (R)-2-Bromobutanoic Acid (CAS 2681-94-9) is a significant chiral building block, widely recognized for its utility in sophisticated organic synthesis and as a precursor for pharmaceutical intermediates. This article explores its scientific underpinnings, detailing its properties, typical synthesis routes, and key applications.

Chemical and Physical Properties

(R)-2-Bromobutanoic Acid, with the molecular formula C4H7BrO2 and a molecular weight of 167.00, is a compound characterized by its chiral center at the alpha-carbon. It typically presents as a colorless to light yellow oil liquid. A critical property to note is its moisture sensitivity, which requires careful storage and handling to maintain its integrity. The predicted boiling point is around 216.6 °C, and its density is approximately 1.625 g/cm³. Its pKa of 2.95 suggests it is a moderately acidic compound.

Synthesis and Manufacturing Insights

The synthesis of enantiomerically pure compounds like (R)-2-Bromobutanoic Acid often involves chiral resolution techniques or enantioselective synthesis methods. While specific proprietary manufacturing processes vary, common approaches might include the stereoselective bromination of butyric acid derivatives or resolution of racemic 2-bromobutanoic acid. Manufacturers, particularly those in China, have optimized these processes to achieve high purity (often 98%+) and significant production volumes. When you buy (R)-2-Bromobutanoic Acid, understanding the quality control measures employed by the manufacturer, such as NMR analysis, is crucial for ensuring the correct stereochemistry and purity.

Key Applications in Chemical Synthesis

The unique chiral nature of (R)-2-Bromobutanoic Acid makes it an invaluable intermediate in various chemical applications:

• Pharmaceutical Intermediates: It serves as a foundational chiral synthon for synthesizing numerous Active Pharmaceutical Ingredients (APIs). The specific stereochemistry is often critical for the therapeutic efficacy and safety of the final drug product.
• Asymmetric Synthesis: Researchers utilize it to introduce chiral centers into target molecules, enabling the creation of specific enantiomers with desired biological or material properties.
• Fine Chemical Production: It’s employed in the synthesis of complex organic molecules for applications ranging from agrochemicals to advanced materials.

Sourcing and Reliability

For scientists and procurement managers, sourcing high-quality (R)-2-Bromobutanoic Acid is facilitated by working with experienced chemical manufacturers and suppliers. Companies that offer detailed technical documentation, adhere to strict quality control, and provide reliable supply chains are preferred. When considering purchasing this chemical, looking for suppliers that clearly list its CAS number (2681-94-9) and purity specifications ensures you are acquiring the correct material for your scientific needs.

The scientific utility of (R)-2-Bromobutanoic Acid underscores its importance in modern chemistry. By understanding its properties and reliable sourcing, professionals can effectively leverage this compound in their research and development endeavors.