NINGBO INNO PHARMCHEM CO.,LTD. is proud to present Seliciclib, also known by its research names like Roscovitine or CYC202, a highly significant chemical compound with the CAS number 186692-46-6. This compound stands as a leading experimental drug candidate within the family of pharmacological cyclin-dependent kinase (CDK) inhibitors. With a molecular formula of C19H26N6O and a molecular weight of 354.45, Seliciclib typically appears as a white to off-white solid, characterized by its high purity, generally 97% Min.

Seliciclib operates by inhibiting multiple enzyme targets, including CDK2, CDK7, and CDK9, which are crucial regulators that influence the growth phase and state within the cell cycle. Its mechanism involves competing at the ATP-binding sites of these kinases, thereby altering cellular processes. Preclinical and ongoing research indicate that Seliciclib induces apoptosis in treated cancerous cells, highlighting its potential in various oncology applications. It has demonstrated activity in non-small cell lung cancer (NSCLC), leukemia, and B-cell lymphomas, including multiple myeloma, by inhibiting RNA polymerase II-dependent transcription and down-regulating proteins like MCL1.

Beyond its anticancer properties, Seliciclib is extensively researched for a wide array of other therapeutic areas. In the realm of immunological disorders, it has shown promise in enhancing the resolution of inflammation by promoting inflammatory cell apoptosis, which could lead to improved treatments for conditions such as cystic fibrosis and arthritis. For neurological therapies, studies have revealed Seliciclib's ability to suppress microglial activation and provide neuroprotection in animal models of cerebral ischemia. Furthermore, it is being explored for increasing the antitumor activity of other agents in treating glioblastoma multiforme.

Seliciclib also exhibits antiviral effects, notably causing the death of cells infected with HIV and preventing the replication of herpes simplex virus. Its diverse biological activities extend to other areas, such as causing parthenogenetic egg activation and reducing renal hypertrophy. These broad applications underscore Seliciclib's versatility as a research chemical.

As a reputable manufacturer and supplier of high-quality pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our Seliciclib (CAS: 186692-46-6) meets stringent purity standards, making it ideal for advanced research and development. Our commitment to excellence provides researchers with a reliable product for their critical studies. For detailed specifications, including its melting point (106-107℃), boiling point (577.5±60.0 °C), and density (1.3±0.1 g/cm3), and proper storage conditions (-20℃), NINGBO INNO PHARMCHEM CO.,LTD. provides comprehensive documentation. Researchers and pharmaceutical companies interested in Seliciclib for their projects are encouraged to inquire about its price and availability. To buy or purchase Seliciclib, please contact NINGBO INNO PHARMCHEM CO.,LTD. directly. We are dedicated to supporting scientific advancement with superior chemical products.