For professionals in the pharmaceutical industry, securing reliable sources for critical intermediates like 1-Benzyl-4-hydroxypiperidine (CAS 4727-72-4) is paramount. This compound, characterized by its white to off-white crystalline powder appearance and a purity typically exceeding 98.0%, plays a pivotal role in the synthesis of various active pharmaceutical ingredients (APIs). Understanding its properties and how to effectively procure it can significantly impact project timelines and final product quality.

Key Properties and Applications

1-Benzyl-4-hydroxypiperidine, also known by synonyms such as 1-benzylpiperidin-4-ol, is a versatile chemical building block. Its molecular formula is C12H17NO, with a molecular weight of approximately 191.27 g/mol. A key feature is its hydroxyl group at the 4-position of the piperidine ring, which provides a reactive site for further chemical modifications. This makes it an indispensable intermediate in the development of pharmaceuticals, particularly those aimed at treating conditions affecting the central nervous system, such as analgesics and psychoactive substances. Its role as a precursor in medicinal chemistry research is well-established, enabling the exploration and synthesis of novel therapeutic agents.

Quality and Specification Considerations

When sourcing this intermediate, attention to specifications is crucial. A purity of ≥98.0% is generally desired, along with a defined melting point range, typically between 61-63°C. These parameters ensure the compound's suitability for complex synthetic routes and guarantee reproducible results in manufacturing processes. As a buyer, it's important to verify that your supplier can consistently provide material that meets these stringent quality standards. Don't hesitate to request Certificates of Analysis (COA) to confirm purity and other critical parameters before placing a bulk order.

Sourcing from Reliable Manufacturers and Suppliers

Identifying a dependable manufacturer and supplier for 1-Benzyl-4-hydroxypiperidine is key to a smooth procurement process. For buyers looking to purchase this chemical, focusing on suppliers with a proven track record, strong quality control measures, and a transparent supply chain is essential. Many pharmaceutical companies source such intermediates from established chemical hubs, with China being a significant global supplier. Engaging with a reputable supplier ensures not only competitive pricing but also adherence to international quality standards and timely delivery. When you need to buy this critical intermediate, seeking quotes from trusted sources will streamline your procurement and support your research and development efforts effectively.