For professionals in the pharmaceutical industry, the consistent and reliable sourcing of high-quality intermediates is paramount. One such critical compound is Ethyl 3,4-bis(2-methoxyethoxy)benzoate, identified by its CAS number 183322-16-9. This specific chemical plays a pivotal role as a key intermediate in the synthesis of Erlotinib, a widely recognized targeted therapy used in the treatment of various cancers, including non-small cell lung cancer and pancreatic cancer. Understanding the importance of this compound and where to procure it reliably is essential for efficient drug manufacturing and development.

The Significance of Ethyl 3,4-bis(2-methoxyethoxy)benzoate in Erlotinib Synthesis

Erlotinib functions by inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase. The complex molecular structure of Erlotinib requires specific, high-purity precursors for its synthesis. Ethyl 3,4-bis(2-methoxyethoxy)benzoate serves as a crucial building block in the multi-step synthesis process, contributing a significant portion of the final Erlotinib molecule's architecture. The purity and quality of this intermediate directly impact the yield and purity of the final Active Pharmaceutical Ingredient (API). Therefore, pharmaceutical manufacturers must secure this component from reputable sources that guarantee stringent quality control and adherence to pharmaceutical standards. If you are looking to buy this essential intermediate, ensure you are partnering with a supplier that can provide Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS).

Sourcing Strategies: Finding Reliable Manufacturers and Suppliers in China

China has emerged as a global hub for the manufacturing of pharmaceutical intermediates and APIs. For businesses seeking Ethyl 3,4-bis(2-methoxyethoxy)benzoate, identifying reliable manufacturers and suppliers in China is a strategic imperative. Key factors to consider when selecting a supplier include their production capacity, quality control systems, regulatory compliance (such as GMP certifications), and their ability to provide consistent supply and competitive pricing. Many Chinese chemical companies specialize in custom synthesis and the production of niche pharmaceutical intermediates, making them ideal partners for global pharmaceutical firms.

When inquiring about purchasing this compound, it is advisable to request detailed product specifications, including purity levels (typically ≥97% or higher for pharmaceutical applications), physical properties (such as appearance and melting point), and packaging details. Furthermore, establishing a strong relationship with a manufacturer that can offer technical support and responsive customer service can streamline the procurement process. Exploring options for bulk purchase can also lead to significant cost savings, making it more feasible for large-scale production runs.

Navigating the Market: Price and Availability Considerations

The price of Ethyl 3,4-bis(2-methoxyethoxy)benzoate can fluctuate based on market demand, raw material costs, and supplier capabilities. Prospective buyers are encouraged to obtain multiple quotes from different manufacturers to ensure they are receiving competitive pricing. Understanding the supplier's lead times and ensuring they can meet your production schedule is also crucial. For R&D purposes, smaller quantities may be readily available, while for commercial manufacturing, long-term supply agreements with trusted producers are often established. By diligently researching and vetting potential suppliers, pharmaceutical companies can secure a steady and cost-effective supply of this vital Erlotinib intermediate, thereby ensuring the uninterrupted production of this critical cancer medication.