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For procurement managers and R&D scientists in the pharmaceutical industry, sourcing high-quality chemical intermediates is paramount. One such critical compound is 3-Ethynylimidazo[1,2-b]pyridazine (CAS: 943320-61-4). This article serves as a comprehensive guide for buyers looking to understand its significance, applications, and most importantly, where to purchase it from reliable manufacturers and suppliers, particularly those based in China.
Understanding the Importance of 3-Ethynylimidazo[1,2-b]pyridazine
3-Ethynylimidazo[1,2-b]pyridazine is primarily recognized for its role as a key intermediate in the synthesis of Ponatinib. Ponatinib is a potent BCR-ABL tyrosine kinase inhibitor used in the treatment of specific types of leukemia, including chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The demand for high-purity intermediates like 3-ethynylimidazo[1,2-b]pyridazine directly correlates with the development and manufacturing of these life-saving oncology drugs. Therefore, ensuring a stable and quality supply is crucial for pharmaceutical companies and research institutions.
Key Specifications for Procurement Managers
When evaluating suppliers for 3-ethynylimidazo[1,2-b]pyridazine, procurement managers should focus on several key specifications. The chemical name is 3-Ethynylimidazo[1,2-b]pyridazine, with the CAS number 943320-61-4 serving as its unique identifier. Typical specifications include an appearance of yellow powder and a high assay, often ≥96.0% or higher, verified by methods like HPLC. Understanding the molecular formula (C8H5N3) and molecular weight (143.145 g/mol) is also fundamental for formulation and process development. Density and refractive index might also be important for specific applications or quality control checks.
Applications in Pharmaceutical Synthesis
The primary application of 3-ethynylimidazo[1,2-b]pyridazine is its use as a critical building block in the multi-step synthesis of Ponatinib. Its ethynyl group and heterocyclic imidazo[1,2-b]pyridazine core provide the necessary structural elements for the final active pharmaceutical ingredient (API). For R&D scientists, this intermediate is invaluable for exploring new synthetic routes or developing related compounds with potential therapeutic benefits. Its role extends to custom synthesis projects where its specific chemical structure is leveraged.
Sourcing Strategies: Finding Reliable Manufacturers and Suppliers in China
China has emerged as a global hub for chemical manufacturing, offering a vast array of pharmaceutical intermediates. When searching to buy 3-ethynylimidazo[1,2-b]pyridazine, it is essential to partner with reputable 3-ethynylimidazo[1,2-b]pyridazine suppliers in China. These suppliers often operate as direct manufacturers or have strong relationships with manufacturing facilities, ensuring better control over quality, pricing, and delivery timelines.
When evaluating potential suppliers, consider the following:
Inquiry and Purchase Process
To purchase 3-ethynylimidazo[1,2-b]pyridazine, you will typically need to submit an inquiry to potential suppliers. This inquiry should clearly state the product name, CAS number, required quantity, and any specific purity or packaging requirements. Many suppliers will then provide a quotation, including the Ponatinib intermediate price, lead time, and shipping information. For bulk orders, direct communication with the 3-ethynylimidazo[1,2-b]pyridazine manufacturer can often lead to more favorable terms and a clearer understanding of the production process.
In conclusion, 3-ethynylimidazo[1,2-b]pyridazine is a vital chemical for the pharmaceutical industry, particularly in the fight against certain cancers. By understanding its specifications and implementing a thorough sourcing strategy, procurement professionals can effectively secure this critical intermediate from reliable manufacturers and suppliers in China, ensuring the continuity and success of their drug development and production efforts.
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