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Sourcing High-Purity Ethyl 3,4-Dihydroxybenzoate for Erlotinib Manufacturing

For professionals in the pharmaceutical industry, especially those involved in the research, development, and manufacturing of oncology drugs, the sourcing of high-quality intermediates is paramount. Ethyl 3,4-Dihydroxybenzoate (CAS: 3943-89-3) stands out as a critical building block, particularly in the synthesis pathway of Erlotinib and its hydrochloride salt. Understanding the importance of this compound and where to reliably source it can significantly impact the efficiency and success of your projects.

Ethyl 3,4-Dihydroxybenzoate, also known by synonyms such as Ethyl Protocatechuate or 3,4-Dihydroxybenzoic Acid Ethyl Ester, is characterized by its molecular formula C9H10O4 and a molecular weight of 182.17300. It typically presents as a white crystalline powder, with purity levels often exceeding 99%, making it suitable for demanding pharmaceutical applications. When you are looking to buy this essential intermediate, especially from a reputable manufacturer in China, attention to purity, consistency, and supplier reliability is key.

The primary application for Ethyl 3,4-Dihydroxybenzoate lies in its role as an intermediate in the synthesis of Erlotinib Hydrochloride (CAS: 183319-69-9) and Erlotinib (CAS: 183321-74-6). Erlotinib is a tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung cancer and pancreatic cancer. The precise chemical structure and high purity of Ethyl 3,4-Dihydroxybenzoate directly influence the yield and quality of the final Active Pharmaceutical Ingredient (API). Therefore, securing a dependable supply of this raw material is a strategic necessity for pharmaceutical manufacturers.

When searching for an 'Ethyl 3,4-Dihydroxybenzoate manufacturer' or 'Ethyl Protocatechuate supplier', it's beneficial to partner with companies that can provide comprehensive product specifications, Certificates of Analysis (CoA), and demonstrate a strong track record in pharmaceutical intermediate production. Companies specializing in pharmaceutical intermediates often offer custom synthesis and contract manufacturing services, catering to varied production scales from kilograms to tons. This flexibility is invaluable for both R&D projects and large-scale commercial production.

The market for pharmaceutical intermediates is competitive, and understanding the 'price of Ethyl 3,4-Dihydroxybenzoate' requires comparing offerings from various suppliers, considering factors like purity, packaging, and delivery terms. For procurement managers, identifying a manufacturer that offers competitive pricing without compromising on quality is crucial. Engaging with suppliers who can provide detailed technical data and regulatory support, such as MSDS and DMF information, further solidifies a robust supply chain.

In summary, if your organization requires Ethyl 3,4-Dihydroxybenzoate for Erlotinib synthesis or related pharmaceutical research, prioritizing a reliable 'CAS 3943-89-3 supplier' is essential. Exploring partnerships with experienced Chinese chemical manufacturers can provide access to high-purity materials, competitive pricing, and the assurance of a stable supply, supporting your ongoing drug development and manufacturing efforts.

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