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In the specialized field of pharmaceutical manufacturing, the selection and procurement of key chemical intermediates are critical for product development and commercial success. Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, identified by its CAS number 256504-39-9, is a prime example of such an indispensable compound. Its primary application lies in serving as a vital intermediate for the synthesis of Riociguat, a pharmaceutical agent used in the treatment of pulmonary hypertension.
The Chemical Profile and Its Significance
With the molecular formula C13H14FN3O2 and a molecular weight of 263.27 g/mol, Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate typically presents as an off-white to yellow solid. A purity assay of ≥98.0% is commonly specified and required, underscoring its importance in ensuring the quality and efficacy of downstream pharmaceutical products. The compound's intricate structure, featuring a pyrazole ring functionalized with an amine group, an ethyl carboxylate ester, and a fluorobenzyl substituent, makes it a versatile building block in complex organic synthesis.
The demand for this intermediate is intrinsically linked to the therapeutic importance of Riociguat. As a stimulator of soluble guanylate cyclase (sGC), Riociguat plays a significant role in managing serious cardiovascular conditions. Consequently, a reliable and consistent supply of high-quality Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is crucial for pharmaceutical companies engaged in its production.
Finding Reliable Chinese Suppliers
For procurement managers and R&D scientists seeking to buy this intermediate, China represents a significant sourcing hub. The Chinese chemical industry offers a vast network of manufacturers specializing in pharmaceutical intermediates. When selecting a supplier, consider these critical aspects:
Many reputable Chinese manufacturers are equipped to supply this compound with the necessary purity and documentation. Engaging with them directly for pricing and availability is a direct route to securing your supply chain.
Conclusion: Securing Your Pharmaceutical Supply
Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is indispensable for the production of Riociguat and represents a key component in the pharmaceutical manufacturing toolkit. By focusing on sourcing from trusted Chinese manufacturers and paying close attention to quality and supply chain reliability, companies can ensure they have access to this vital intermediate. Reaching out for a quote is the recommended first step to establishing a productive partnership.
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