The global demand for effective pharmaceuticals continues to grow, driving innovation and the need for reliable sourcing of key chemical intermediates. For manufacturers of Pregabalin, a widely prescribed medication for neuropathic pain, epilepsy, and fibromyalgia, securing a consistent supply of high-quality intermediates is paramount. Among these, 3-Isobutylglutaric Acid (CAS 75143-89-4) stands out as a critical component.

Understanding the role and sourcing of 3-Isobutylglutaric Acid is essential for procurement managers and R&D scientists in the pharmaceutical industry. As a leading manufacturer and supplier of fine chemicals in China, we aim to provide clarity on this vital compound.

What is 3-Isobutylglutaric Acid?

3-Isobutylglutaric Acid, also known by its IUPAC name 3-(2-Methylpropyl)pentanedioic acid, is an organic compound with the molecular formula C9H16O4 and CAS number 75143-89-4. It presents as a white to pale brown solid with a molecular weight of 188.22 g/mol. Its chemical structure makes it a valuable building block in complex organic syntheses.

Key Applications in Pharmaceutical Manufacturing

The primary application of 3-Isobutylglutaric Acid is its role as a crucial intermediate in the synthesis of Pregabalin. Pregabalin is an analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and its synthesis involves several steps where 3-Isobutylglutaric Acid plays a pivotal part. Ensuring a high purity level (typically ≥99.0%) of this intermediate is critical to guarantee the efficacy and safety of the final Pregabalin API. Procurement managers looking to buy this intermediate must prioritize suppliers who can consistently deliver material meeting these stringent specifications.

Furthermore, 3-Isobutylglutaric Acid is recognized as a Pregabalin impurity. Its presence, even in trace amounts, necessitates its use as a reference standard for analytical method development and validation in pharmaceutical quality control. This ensures that manufacturers can accurately identify and quantify impurities, maintaining the integrity of their drug products.

Sourcing from China: Advantages for Buyers

China has emerged as a global powerhouse for chemical manufacturing, offering a vast array of intermediates and APIs at competitive price points. For 3-Isobutylglutaric Acid, sourcing from reputable Chinese manufacturers can offer significant advantages:

• Cost-Effectiveness: Chinese manufacturers often provide more competitive price options, especially for bulk orders, which can significantly impact overall production costs.
• Scalability and Capacity: Leading Chinese chemical companies possess large-scale production facilities capable of meeting high-volume demands, ensuring a stable supply chain for large pharmaceutical operations.
• Established Expertise: Many Chinese manufacturers have decades of experience in fine chemical synthesis, developing mature technologies and robust quality control systems.

When seeking to purchase 3-Isobutylglutaric Acid, buyers should conduct thorough due diligence. Look for suppliers who provide detailed product specifications, certificates of analysis (CoA), and are transparent about their manufacturing processes and quality management systems. Engaging with established suppliers, such as those offering this product in China, can streamline your procurement process and mitigate risks.

Navigating the Procurement Process

For procurement professionals, the process of sourcing 3-Isobutylglutaric Acid involves identifying reliable partners. Key considerations include:

• Supplier Reputation: Research the supplier's history, certifications (e.g., ISO), and customer testimonials.
• Product Specifications: Ensure the purity, physical characteristics (appearance), and CAS number match your requirements.
• Pricing and MOQ: Obtain quotes for your desired quantities and understand the Minimum Order Quantity (MOQ).
• Lead Times and Logistics: Clarify delivery timelines and shipping options to ensure they align with your production schedule.

By leveraging the strengths of the Chinese chemical market and partnering with trusted suppliers, pharmaceutical companies can ensure a consistent and cost-effective supply of 3-Isobutylglutaric Acid, thereby supporting the continuous availability of essential medications like Pregabalin.