For pharmaceutical companies engaged in the synthesis of advanced therapeutic agents, securing reliable sources of high-quality intermediates is paramount. One such critical compound is the Rolapitant Intermediate, identified by CAS number 1214741-21-5. This article aims to guide procurement managers and R&D scientists in effectively sourcing this vital chemical building block. Understanding its significance and identifying reputable suppliers can streamline your production process and ensure the efficacy of the final drug product.

Understanding the Rolapitant Intermediate (CAS 1214741-21-5)

The compound 3-(1,1-diMethylethyl)-7a-ethenyltetrahydro-1-hydroxy-(3R,7aR)-3H,5H-Pyrrolo[1,2-c]oxazol-5-one, commonly known as Rolapitant Intermediate 1, is a key precursor in the synthesis of Rolapitant. Rolapitant is a selective NK1 receptor antagonist, primarily used for the prevention of chemotherapy-induced nausea and vomiting (CINV). The precise stereochemistry and purity of this intermediate are critical for the successful synthesis of the active pharmaceutical ingredient (API). Therefore, when you buy Rolapitant Intermediate 1214741-21-5, prioritizing quality and consistent supply is essential.

Key Considerations for Sourcing

When looking to purchase CAS 1214741-21-5, several factors should be carefully evaluated:

• Purity and Specifications: Confirm that the supplier can provide the intermediate with the required purity levels, often exceeding 98.5% via HPLC, and with high enantiomeric excess (e.e. >99.0%) if stereochemical purity is paramount for your process. Request Certificates of Analysis (CoA) for each batch.
• Manufacturer Reliability: Partnering with a reputable CAS 1214741-21-5 manufacturer from China or other established chemical production hubs ensures better quality control and supply stability. Look for suppliers with strong production capacities and adherence to international quality standards like ISO.
• Supply Chain Stability: A consistent and dependable supply is crucial for continuous manufacturing. Evaluate the supplier's production capacity and their ability to meet your ongoing demand. Working with an experienced pharmaceutical intermediate supplier in China can often offer competitive advantages in terms of cost and production scale.
• Regulatory Compliance: Ensure the supplier can provide necessary documentation, such as Material Safety Data Sheets (MSDS) and potentially Drug Master Files (DMF) or equivalent, depending on your project phase and regulatory requirements.
• Pricing and Commercial Terms: While quality is primary, competitive pricing is also a significant factor. Compare quotes from various suppliers, considering payment terms, Incoterms (e.g., FOB, CIF), and minimum order quantities (MOQ). You should be able to buy high purity chemical intermediate for sale at reasonable market rates.

Navigating the Purchase Process

To secure your supply of Rolapitant Intermediate, initiate contact with potential suppliers. Clearly state your requirements, including the CAS number, desired quantity, purity specifications, and delivery timeline. Requesting a quotation and a sample for evaluation is a standard practice. Once a supplier is chosen, establish clear communication channels and understand their order fulfillment process. Effective collaboration with your Rolapitant Intermediate manufacturer will be key to success.

By focusing on these aspects, pharmaceutical professionals can confidently source the necessary intermediates to support their drug development and manufacturing efforts. A strategic approach to supplier selection ensures you procure the highest quality Rolapitant Intermediate, enabling efficient and successful synthesis of your target APIs.