NINGBO INNO PHARMCHEM CO.,LTD. is a reputable source for high-quality active pharmaceutical ingredients and fine chemicals. Among our key offerings is Afoxolaner, identified by its CAS number 1093861-60-9. Available as a high-purity raw material, typically 99% minimum, Afoxolaner is a prominent compound in veterinary medicine, specifically recognized for its potent antiparasitic properties. It belongs to the isoxazoline class of insecticides and acaricides, playing a crucial role in the control of common external parasites affecting companion animals. This raw material is supplied in a white or almost white lyophilized powder form, conforming to strict quality standards.

The mechanism of action behind Afoxolaner's effectiveness is distinct and targets the nervous systems of susceptible arthropods. Afoxolaner acts non-competitively on gamma-aminobutyric acid (GABA) receptors and glutamate-gated chloride channels found in insects and acarids. By binding to these sites, it blocks the transfer of chloride ions across cell membranes. This inhibition leads to excessive neuronal stimulation, uncontrollable activity in the muscles and nervous system, and ultimately results in the paralysis and death of the parasite. This targeted action minimizes impact on mammalian hosts, where these receptor types are either absent or have different sensitivities.

Clinical studies and field usage have demonstrated the significant efficacy of orally administered Afoxolaner. For instance, a single oral dose has shown high effectiveness in eliminating pre-existing tick infestations and preventing re-infestation for up to a month. Its classification as an isoxazoline highlights its modern approach to parasite control. The product meets stringent quality parameters, aligning with standards such as BP, USP, EP, and in-house specifications, ensuring its suitability for pharmaceutical applications. The molecular formula is C26H17ClF9N3O3, and the molecular weight is 625.87000.

As a dedicated manufacturer and supplier of pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. provides Afoxolaner CAS 1093861-60-9 in various packaging options to meet different client needs, including 5kg tins, 10kg tins, and 25kg drums. We ensure reliable supply chain management and maintain high production capacity to support both small-scale and bulk orders. For those looking to buy or purchase Afoxolaner powder, detailed product specifications, sample availability, and competitive pricing information can be readily obtained by contacting our sales team. We aim to be your preferred supplier for high-quality veterinary active ingredients.