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Microcrystalline Cellulose (MCC) is a vital pharmaceutical excipient, and its performance is intrinsically linked to its synthesis process and resulting physicochemical properties. Understanding these factors is crucial for effective formulation development.
The primary method for producing MCC involves the acid hydrolysis of purified alpha-cellulose, typically derived from wood pulp. This process selectively removes amorphous regions of the cellulose fiber, leaving behind the highly crystalline, microcrystalline domains. The resulting powder is then washed and dried, often via spray-drying, to achieve specific particle size distributions and moisture contents. Variations in hydrolysis conditions (acid concentration, temperature, time) and drying parameters can significantly impact the MCC's final properties.
Key physicochemical properties of MCC include its moisture content, particle size, and degree of crystallinity. Moisture content can influence compaction properties and flowability; higher moisture content may improve lubrication sensitivity but can also lead to particle aggregation. Particle size is critical for flow and compressibility, with finer particles generally offering better binding but potentially poorer flow compared to coarser grades.
Crystallinity, while generally high in MCC, can subtly affect water absorption and API interactions. The bulk density of MCC also plays a role, with lower densities often correlating to better compressibility but potentially poorer flow. These characteristics collectively determine MCC's suitability for various applications, from direct compression tableting to wet granulation, and highlight the importance of sourcing MCC with precisely controlled attributes.
By carefully managing these physicochemical properties through controlled synthesis, manufacturers can produce MCC grades optimized for specific pharmaceutical, food, and cosmetic applications, ensuring consistent performance and product quality.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
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