The field of chemical synthesis, particularly the creation of complex molecules like peptides, relies fundamentally on efficient and reliable reagents. Among the critical steps in peptide synthesis is the formation of the amide bond between amino acids. This process requires specific coupling reagents that facilitate the reaction with high yield and minimal side products. Selecting the right coupling agent is paramount for success in both research and large-scale peptide production.

One such highly regarded coupling reagent is N, N, N′, N′-Tetramethyl-O-(BENZOTRIAZOL-1-YL) Uronium Tetrafluoroborate, commonly known by its acronym, TBTU. Identified by the Chemical Abstracts Service (CAS) number 125700-67-6, TBTU has become a staple in synthetic chemistry laboratories worldwide, especially for its efficacy in solid-phase peptide synthesis (SPPS).

TBTU is typically supplied as a white powder, indicating its solid form which is convenient for handling and storage. Its chemical structure is defined by the molecular formula C11H16BF4N5O and it has a molecular weight of 321.09. The substance is also indexed under the EINECS number 603-087-9. As a uronium salt-based coupling agent, TBTU belongs to a class of reagents known for their potent activation capabilities.

The primary application of TBTU (CAS 125700-67-6) is as a coupling reagent in the formation of peptide bonds. It functions as a multifunctional reagent adept at activating carboxylic acids. In peptide synthesis, this means that amino acids can react directly with amines in a single, efficient step. This eliminates the need for pre-activation of the acid component, simplifying the synthetic procedure and reducing overall reaction time. Its utility in solid-phase peptide synthesis is particularly valued, where it helps ensure high coupling yields on the solid support, a critical factor for synthesizing long and complex peptide sequences.

The advantages associated with using TBTU are significant. The reaction processes utilizing TBTU are widely recognized for being both convenient and practical. It facilitates rapid in situ activation of the carboxyl group, allowing the coupling reaction to proceed swiftly. A key benefit is the tendency for small side reactions, which contributes directly to the higher purity of the synthesized peptide product. This is particularly important in pharmaceutical applications where product purity is strictly regulated. TBTU is commercially available and demonstrates good stability under proper storage conditions, making it a reliable reagent for routine use.

Furthermore, TBTU exhibits solubility in a wide range of solvents, including polar organic solvents commonly used in peptide synthesis, and notably, it can also dissolve in water. This broad solvent compatibility offers chemists flexibility in reaction design and optimization. The by-products formed during TBTU-mediated couplings are generally easy to remove, simplifying downstream purification processes and improving overall workflow efficiency.

In the context of modern chemical synthesis, particularly the demanding field of peptide and protein science, the quality and reliability of reagents like TBTU (CAS 125700-67-6) are non-negotiable. The performance of the coupling reaction directly impacts the yield, purity, and success rate of peptide synthesis. Impurities in coupling reagents can lead to truncated sequences, unwanted modifications, or difficulties in purification, ultimately increasing costs and delaying projects.

For laboratories and manufacturing facilities seeking a dependable source for high-quality N, N, N′, N′-Tetramethyl-O-(BENZOTRIAZOL-1-YL) Uronium Tetrafluoroborate (CAS 125700-67-6), partnering with a reputable chemical *manufacturer* and *supplier* is essential. Ensuring the reagent meets stringent purity standards is crucial for achieving reproducible and optimal results in sensitive synthetic applications like peptide synthesis.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated *manufacturer* and *supplier* offering high-quality TBTU (CAS 125700-67-6) powder. Our product is manufactured under strict quality control protocols to ensure its suitability for the most demanding applications, from research and development to large-scale peptide production. We understand the critical role that a reliable coupling reagent plays in your synthesis work.

To inquire about the price of our TBTU or to buy / purchase this essential coupling reagent, interested parties are encouraged to contact NINGBO INNO PHARMCHEM CO.,LTD. directly. As a trusted *supplier*, we are committed to providing not only high-purity products but also reliable service and support. Our team can provide detailed product specifications, discuss bulk *purchase* options, and offer competitive price structures tailored to your specific requirements. Securing a consistent supply of high-purity TBTU from a trusted *manufacturer* and *supplier* like NINGBO INNO PHARMCHEM CO.,LTD. is a strategic step towards optimizing your peptide synthesis processes and ensuring successful outcomes. Whether you are looking to buy TBTU for small-scale laboratory experiments or large-scale industrial synthesis, partnering with an experienced and reliable chemical provider ensures you receive material that consistently meets your exact needs, facilitating efficient and pure peptide bond formation.