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For API manufacturers, the selection of chemical intermediates is a critical decision impacting product quality, regulatory compliance, and production efficiency. 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole (CAS 97963-62-7) is a prime example of such an intermediate, indispensable for the synthesis of pantoprazole. As a leading manufacturer, we provide detailed technical information to support your procurement process.
Chemical Properties and Specifications
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole presents as a white or almost white crystalline powder. Its chemical formula is C8H6F2N2OS, with a molecular weight of 216.21 g/mol. A key specification is its high purity, with an assay typically ≥99.5%. This level of purity is vital for ensuring the efficiency of subsequent reaction steps and the quality of the final API. The compound's melting point, around 239-243 °C, and its solubility characteristics (e.g., slightly soluble in DMSO and Methanol) are important parameters for process chemists to consider during reaction design and optimization.
Role in Pantoprazole Synthesis
The primary application of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole is as a key precursor in the multi-step synthesis of pantoprazole. This involves a coupling reaction with a pyridinylmethyl derivative, followed by oxidation. The integrity and purity of this intermediate directly influence the overall yield and the profile of impurities in the final pantoprazole API. Manufacturers worldwide rely on consistent, high-quality supply to maintain GMP compliance and ensure product efficacy. We understand these demands and are committed to delivering a product that meets the most rigorous pharmacopeial standards, including USP, BP, and EP.
Beyond Pharmaceuticals: Broader Chemical Utility
While its pharmaceutical role is dominant, 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole also serves as a valuable building block in broader organic synthesis. Its functional groups allow for its use in preparing:
Procurement Considerations for API Manufacturers
When sourcing this intermediate, API manufacturers should prioritize suppliers who can demonstrate:
As a dedicated China manufacturer, we offer direct access to high-purity 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole. We invite your technical and procurement teams to contact us for detailed specifications, sample requests, and to discuss bulk purchase options. Partnering with us ensures a secure and high-quality supply for your API manufacturing needs.
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