Teriparatide Acetate: A Breakthrough in Osteoporosis Treatment and Bone Health Enhancement

Osteoporosis, a debilitating condition characterized by weakened bones and increased fracture risk, poses a significant global health challenge. Among the advanced therapeutic options available, Teriparatide Acetate stands out as a unique and highly effective anabolic agent that actively stimulates new bone formation. This distinguishes it from traditional anti-resorptive drugs that primarily work by inhibiting bone breakdown. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Teriparatide Acetate, ensuring its availability for critical medical applications worldwide.

Chemically known as Teriparatide Acetate with CAS No. 99294-94-7, this active pharmaceutical ingredient is a synthetic form of human parathyroid hormone, specifically the biologically active 1-34 amino acid fragment. Its molecular formula is C181H291N55O51S2, with a molecular weight of 4117.70, typically presented as a white to off-white powder with an assay of at least 98.0%. This polypeptide acts directly on osteoblasts, the bone-building cells, to promote their activity and increase their number, leading to an overall increase in bone mass and improved bone microarchitecture.

The primary therapeutic application of Teriparatide Acetate is in the management of osteoporosis. It is particularly indicated for:

• Postmenopausal women with osteoporosis who are at high risk for fracture or who have failed or are intolerant to other available osteoporosis therapies. Studies have shown a significant reduction in both vertebral and nonvertebral fractures in this patient group.
• Men with primary or hypogonadal osteoporosis who are also at high risk for fracture or cannot tolerate other treatments. It effectively increases bone mass in these individuals.
• Men and women with osteoporosis associated with sustained systemic glucocorticoid therapy, a common cause of secondary osteoporosis, especially in patients with a high risk of fracture.

The mechanism of action is crucial to understanding its efficacy. Teriparatide Acetate binds to the parathyroid hormone type 1 receptor (PTH1R), mimicking the intermittent effects of endogenous parathyroid hormone. Unlike continuous high levels of PTH, which can lead to bone resorption, the once-daily, intermittent administration of Teriparatide Acetate preferentially stimulates osteoblastic function, thereby promoting net bone formation. This results in significant improvements in bone mineral density (BMD) at key skeletal sites, including the lumbar spine and hip, contributing to enhanced bone strength and resilience.

Administration is typically via subcutaneous injection, usually into the thigh or abdominal area, at a recommended dose of 20 mcg once daily. Patients often receive initial doses in a controlled setting to monitor for transient orthostatic hypotension, a mild and usually self-resolving side effect. Historically, treatment duration was limited to two years due to concerns related to animal studies. However, recent label changes, supported by extensive post-marketing surveillance, indicate that the lifetime treatment limitation has been removed for high-risk patients, allowing for extended therapy when clinically justified. This provides clinicians with greater flexibility in managing severe cases of osteoporosis.

For those looking to secure a reliable Teriparatide Acetate supply, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive Teriparatide Acetate price options and flexible packaging solutions, including 25 kg/drum or customized according to specific customer requirements. Our commitment to quality ensures that our product meets stringent purity standards, with an assay of ≥98.0%, making us a trusted Teriparatide Acetate manufacturer and Teriparatide Acetate supplier. Interested parties are encouraged to contact us to buy Teriparatide Acetate and discuss their specific procurement needs. We strive to provide comprehensive support and competitive offerings for businesses seeking to purchase Teriparatide Acetate in bulk or for specialized applications, maintaining transparent processes and reliable logistics for your peace of mind.