In the relentless pursuit of novel therapeutics, the role of specialized chemical intermediates cannot be overstated. tert-Butyl N-(4-bromobutyl)carbamate, designated by CAS 164365-88-2, is one such compound that plays a pivotal role in the synthesis of promising drug candidates. This article delves into the specific applications of this key pharmaceutical intermediate, illustrating its significance for researchers and formulators seeking to buy high-quality materials from reliable manufacturers.

A Versatile Building Block for Pharmaceutical Innovation

The chemical structure of tert-Butyl N-(4-bromobutyl)carbamate, featuring a reactive bromide and a protected amine, makes it an exceptionally versatile building block in complex organic synthesis. This dual functionality allows chemists to selectively modify different parts of the molecule, leading to a diverse range of derivatives with tailored pharmacological properties. For pharmaceutical companies and contract research organizations (CROs), having a consistent and high-quality source for this intermediate is essential for advancing their research pipelines.

Applications in Anti-HIV Agent Development

One of the significant applications of tert-Butyl N-(4-bromobutyl)carbamate is in the synthesis of aloperine derivatives. Research has shown that these derivatives exhibit potential as HIV-1 entry inhibitors. By utilizing this intermediate, scientists can construct novel molecular architectures designed to interfere with the virus's ability to infect host cells. The ability to purchase this compound from a reputable supplier enables researchers to efficiently scale up their synthesis efforts and explore the therapeutic potential of these aloperine analogs.

Contribution to CK2 Inhibitor Research

Furthermore, tert-Butyl N-(4-bromobutyl)carbamate is instrumental in the modification of existing compounds to create improved CK2 inhibitors. Protein kinase CK2 is implicated in various cellular processes and diseases, including cancer. Developing selective CK2 inhibitors is a key area of research. This intermediate serves as a scaffold or linking unit to attach functional groups that enhance binding affinity, selectivity, and pharmacokinetic properties of potential CK2 inhibitors. When sourcing this material, focusing on purity and reliable delivery from established chemical manufacturers is paramount for ensuring the reproducibility of experimental results.

Sourcing Strategy for R&D Professionals

For professionals in drug discovery, procuring tert-Butyl N-(4-bromobutyl)carbamate (CAS 164365-88-2) often involves partnering with specialized chemical suppliers. When considering a purchase, it is crucial to evaluate the supplier's expertise in pharmaceutical intermediates, their commitment to quality control, and their ability to provide comprehensive technical documentation. Manufacturers in China are often well-positioned to offer competitive pricing and a broad range of services, including custom synthesis if specific modifications are required. Always request a Certificate of Analysis (CoA) to confirm the purity and specifications of the material before committing to a purchase.

In summary, tert-Butyl N-(4-bromobutyl)carbamate is more than just a chemical reagent; it is an enabler of critical advancements in pharmaceutical research. Its applications in developing potential anti-HIV agents and enhancing CK2 inhibitors highlight its value, making it a sought-after intermediate for any forward-thinking research and development team.