Introduction to Tetrahydroharmine CAS 17019-01-1

Tetrahydroharmine (THH), identified by its CAS number 17019-01-1, is a significant β-carboline alkaloid. This compound is naturally sourced from plants belonging to the *Peganum* genus, most notably *Peganum harmala*, commonly known as Syrian rue. It holds structural similarities to other well-known alkaloids like harmine and harmaline, distinguishing itself through the presence of a fully saturated dihydropyrrole ring within its chemical structure. Presented typically as a fine powder, ranging in color from white to light yellow, Tetrahydroharmine is recognized for its distinct chemical properties and its potential for various applications.

Chemical Profile and Properties

The chemical formula for Tetrahydroharmine is C13H16N2O, with a molecular weight of 216.28 g/mol. As a crystalline powder, it exhibits a melting point generally found between 195 and 198°C. Its solubility profile indicates that it is sparingly soluble in water but demonstrates better solubility in organic solvents. Purity is a critical factor for its intended uses, with high-grade material typically exceeding 98% purity. Proper storage is essential to maintain its stability and efficacy; it is recommended to store Tetrahydroharmine in a cool and dry place, ideally at temperatures between 2-8°C, away from strong light and heat. Under these conditions, it possesses a shelf life of approximately two years.

Biological Activity and Applications

Tetrahydroharmine's biological activity is primarily centered around its effects on the Central Nervous System (CNS). A key characteristic is its function as a reversible monoamine oxidase inhibitor (MAOI). This mechanism allows it to potentially influence the levels of important neurotransmitters in the brain, including serotonin and dopamine. This biochemical interaction is thought to contribute to some of the mild psychoactive effects associated with its use or the use of plants containing it.

Historically, THH has found its place in traditional medicinal practices. It has been utilized for its purported sedative, anxiolytic (anxiety-reducing), and anti-inflammatory properties. However, it is crucial to note that modern clinical applications are currently limited, and its use is often restricted or regulated.

Significant research interest surrounds Tetrahydroharmine, particularly in the field of neurological studies. Scientists are exploring its potential in remedying various neurological disorders, investigating how its MAOI activity and potential neuroprotective properties could be leveraged. It is also a known component of certain plant preparations used in traditional contexts, although its role is often considered secondary to other psychoactive alkaloids present.

Due to its psychoactive potential and association with certain traditional practices, the safety and legal status of Tetrahydroharmine vary globally. High doses can lead to adverse effects such as nausea and vomiting, and its MAOI activity necessitates caution regarding potential interactions with other pharmaceuticals.

Quality and Standards

Ensuring the quality of Tetrahydroharmine is paramount, especially for research and potential pharmaceutical applications. Reputable suppliers adhere to stringent quality control measures. Analytical techniques such as High-Performance Liquid Chromatography (HPLC) are routinely employed to verify purity and identity. Furthermore, adherence to international standards and certifications such as GMP, HSE, ISO 9001, USP, BP, and SGS indicates a commitment to quality and consistency in production and handling.

Sourcing and Availability

For researchers, formulators, and manufacturers requiring high-purity Tetrahydroharmine powder (CAS 17019-01-1), reliable sourcing is essential. The minimum order quantity (MOQ) typically starts from 1kg, catering to research and development needs as well as initial production batches. Packaging is designed to protect the integrity of the product, often involving vacuum-sealed foil bags or drums, ensuring stability during transport and storage. When considering sourcing options, potential buyers will look for a trusted Tetrahydroharmine manufacturer and Tetrahydroharmine supplier.

Factors influencing the Tetrahydroharmine price include purity, quantity ordered, and the supplier's quality standards. To buy Tetrahydroharmine or purchase Tetrahydroharmine, it is advisable to engage directly with established chemical suppliers who can provide detailed product specifications, certificates of analysis, and ensure proper handling and shipment logistics. NINGBO INNO PHARMCHEM CO.,LTD. is a key partner for sourcing this high-quality raw material, supporting global research and development efforts.

Conclusion

Tetrahydroharmine CAS 17019-01-1 stands as a fascinating β-carboline alkaloid with a history in traditional uses and significant ongoing research interest in its potential neurological applications, particularly stemming from its MAOI activity. As a pure powder, it serves as a valuable raw material for scientific study and potential future developments. Sourcing this compound requires attention to quality, purity, and regulatory considerations. NINGBO INNO PHARMCHEM CO.,LTD. provides a reliable avenue for those seeking to purchase high-quality Tetrahydroharmine for their research or manufacturing needs. Researchers and industry professionals are encouraged to explore the potential of this compound responsibly.