The field of molecular biology and cellular research relies on a sophisticated arsenal of chemical tools to unravel complex biological processes. Among these, (S)-10-Hydroxycamptothecin (CAS 19685-09-7) stands out due to its profound impact on DNA replication and its potential in therapeutic applications. This compound, a derivative of the natural product camptothecin, is a powerful inhibitor of DNA topoisomerase I, making it a cornerstone for research into cellular mechanisms and cancer therapy.

Topoisomerase I is an enzyme indispensable for managing DNA topology. During critical cellular events like replication and transcription, DNA becomes supercoiled. Topoisomerase I resolves these topological stresses by introducing transient single-strand breaks, allowing the DNA to unwind, and then religating the breaks. (S)-10-Hydroxycamptothecin's biochemical action is to trap this enzyme-DNA complex. By binding to and stabilizing the cleavable complex, it prevents the religation step. This intervention leads to the accumulation of DNA breaks, which triggers cellular responses such as cell cycle arrest, particularly in the G2/M phase, and ultimately, apoptosis. This precise mechanism makes it an invaluable probe for studying DNA dynamics and cell death pathways.

For researchers, obtaining a reliable supply of (S)-10-Hydroxycamptothecin is crucial for accurate and reproducible experiments. As a dedicated manufacturer and supplier, we provide this high-purity compound, ensuring that your studies into DNA topoisomerase I inhibition are based on a foundation of quality. Whether you are investigating its effects on specific cell lines, exploring resistance mechanisms, or using it as a scaffold for developing new therapeutic molecules, our product is designed to meet your scientific needs.

The enhanced solubility and cytotoxic activity of (S)-10-Hydroxycamptothecin compared to its precursor, camptothecin, also contribute to its widespread use. These improved properties allow for more effective experimental designs and potentially better therapeutic outcomes in preclinical models. When you purchase this compound from us, you are investing in a product that supports cutting-edge biochemical research and pharmaceutical innovation. We offer competitive price points, especially for bulk orders, reflecting our commitment to making vital research chemicals accessible.

Understanding the biochemical significance of (S)-10-Hydroxycamptothecin is key to appreciating its role in advancing scientific knowledge. Its targeted inhibition of topoisomerase I provides a powerful means to study DNA repair, cell cycle regulation, and the development of targeted cancer therapies. As a trusted supplier, we are proud to contribute to these vital research endeavors by providing a consistent and high-quality source of this essential compound.