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Understanding the precise chemical and physical properties of intermediates is fundamental for their successful application in synthesis and manufacturing. 2-(7-Methoxynaphthalen-1-yl)acetic Acid (CAS: 6836-22-2), a key compound in pharmaceutical synthesis, possesses a distinct set of characteristics that dictate its handling, storage, and reactivity. NINGBO INNO PHARMCHEM CO.,LTD. provides essential insights into these properties, ensuring users can leverage this intermediate effectively and safely.
Physically, 2-(7-Methoxynaphthalen-1-yl)acetic Acid is typically described as a light yellow powder. Its solid form, with a melting point in the range of 153-154°C, indicates a stable crystalline structure. This characteristic is important for its handling and storage, as it suggests good shelf-life when kept under appropriate conditions. The density of the compound is reported as 1.235 g/cm³, providing an indication of its molecular packing. The solubility profile, showing slight solubility in dichloromethane and methanol, is also a key parameter for chemists designing reaction and purification protocols. NINGBO INNO PHARMCHEM CO.,LTD. ensures that detailed specifications are available for all products.
Chemically, 2-(7-Methoxynaphthalen-1-yl)acetic Acid is characterized by its carboxylic acid functional group (-COOH) and the presence of a methoxy group (-OCH3) attached to a naphthalene ring system. This combination imparts specific reactivity. The carboxylic acid group allows for nucleophilic acyl substitution reactions, making it amenable to forming esters, amides, and acid halides. The aromatic naphthalene system can participate in electrophilic substitution reactions, although the existing substituents will influence regioselectivity. These properties are critical for its role as an intermediate in the synthesis of Agomelatine and for its potential in other organic synthesis applications.
Safe handling and storage are paramount when working with any chemical substance. For 2-(7-Methoxynaphthalen-1-yl)acetic Acid, it is recommended to store it in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible materials. Its flash point of 160.7°C suggests a degree of thermal stability, but standard laboratory safety practices, including the use of personal protective equipment (PPE) such as gloves, eye protection, and lab coats, should always be followed. NINGBO INNO PHARMCHEM CO.,LTD. provides comprehensive Safety Data Sheets (SDS) for all its products, offering detailed guidance on safe handling, storage, and emergency procedures. Understanding these properties is key to unlocking the full synthetic potential of this important chemical intermediate.
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