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The Chemical Properties and Synthesis of UMP (CAS 58-97-9)

Uridine 5'-Monophosphate (UMP), identified by CAS 58-97-9, is a complex nucleotide with a specific chemical structure that dictates its diverse biological functions and applications. Understanding these chemical properties and synthesis pathways is fundamental for professionals involved in its procurement and utilization.

Chemically, UMP is a ribonucleoside monophosphate. Its structure comprises three key components: a phosphate group, a pentose sugar (ribose), and a nitrogenous base (uracil). This molecular architecture, with the formula C9H13N2O9P and a molecular weight of approximately 324.18 g/mol, is central to its role as a monomer in RNA. The 'white powder' appearance and its solubility in water are indicative of its polar nature, which influences its handling and formulation.

The synthesis of UMP can be achieved through various chemical and enzymatic routes. Traditional chemical synthesis often involves multi-step processes starting from uridine and phosphoric acid derivatives. These methods, while effective in producing UMP, can sometimes be complex and require careful control of reaction conditions to achieve high purity. For industrial-scale production, efficiency and cost-effectiveness are key considerations when selecting a synthesis route. Manufacturers often optimize these processes to ensure a consistent supply of UMP meeting stringent specifications.

Enzymatic synthesis offers an alternative pathway, utilizing specific enzymes to catalyze the formation of UMP. These biocatalytic methods can offer advantages such as higher specificity, milder reaction conditions, and reduced environmental impact. For instance, uracil phosphoribosyltransferase from thermophilic organisms has been explored for its ability to synthesize modified nucleoside-5′-monophosphates, including UMP. The choice between chemical and enzymatic synthesis often depends on the desired purity, scale of production, and economic feasibility.

As a 'pharmaceutical intermediate' and 'biochemical reagent,' the stability and reactivity of UMP are important. It can undergo various reactions, including phosphorylation to form UTP, and is susceptible to hydrolysis under certain conditions. Therefore, proper storage—typically at -20°C—and careful handling are crucial to maintain its integrity and efficacy. Buyers seeking to 'buy UMP' should inquire about recommended storage conditions and shelf life from their chosen 'manufacturer or supplier'.

The detailed understanding of UMP's chemical properties and synthesis routes empowers B2B clients to make informed decisions. Whether seeking UMP for pharmaceutical applications, nutritional supplements, or research, knowledge of its chemical nature ensures optimal use and procurement from a reliable 'supplier in China' or elsewhere.

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